Nano-scale Characterization of 3-Dimensional Hybrid Scaffolds for Bone Tissue Engineering

M.J. Wozniak 1, P. Oberbek 2, A. Chlanda 2, L. John 3, P. Sobota 3 and K.J. Kurzydlowski 2

1. University Research Centre – Functional Materials, Warsaw University of Technology
2. Faculty of Materials Science and Engineering, Warsaw University of Technology
3. Faculty of Chemistry, University of Wroclaw

There is a growing need for bone regeneration due to various clinical bone diseases such as bone infections, bone tumors and bone loss by trauma. This can be reached by bone tissue engineering. The bone has a complex hierarchical structure. This structural hierarchy plays a major part in determining the bulk material properties.[1] The modern biomaterials should be nontoxic and mimic cells native in vivo environment as closely as possible, support and enhance tissue repair. [2-5] To mimic natural extracellular matrix (ECM) the hierarchical characterization of engineered scaffolds is needed. In this work we are presenting the results of 3-dimensional hybrid scaffolds characterization from micro to nano scale. The combination of Micro-CT, Electron Microscopy, Scanning Probe Microscopy and related techniques gives unique opportunity for comprehensive analysis of the biomaterial morphology and their physical properties.

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