Solid Self Micro Emulsifying Drug Delivery System of Diacerein
Durgacharan A. Bhagwat, Priyanka B. Patil, John I. D’Souza
Tatyasaheb Kore College of Pharmacy, Warananagar, Tal: Panhala, Dist: Kolhapur 416 113. Maharashtra, India
Durgacharan Arun Bhagwat M. Pharm.(Industrial Pharmacy): Pursuing Ph.D. from JJT University, Rajasthan, completed UG from Shivaji University, Kolhapur and PG from SGB Amravati University and presently working as Asst. Professor Dept. of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar. He has 5.2 yrs of teaching experience. He published 1 Book and 19 research papers in National and International journals of repute and presented more than 40 papers at various National and International conferences. Research interest include Development of Novel Drug Delivery System.
The objectives of the present study to develop solid self micro emulsifying drug delivery system (S-SMEDDS) of poorly water soluble drug diacerein. The screened potential micro emulsion components of SMEDDS were ethyl oleate, tween 80, Cremophore RH 40 and the concentration of the same was optimized on the basis of pseudoternary phase diagram. The SMEDDS was characterized for dispersibility test, globule size, and thermodynamic stability testing. The S-SMEDDS was prepared by spray drying the liquid SMEDDS in lab scale spray dryer with maltodextrin as solid carrier. S-SMEDDS were characterized for their reconstitution properties, globule size, zeta potential, drug content and in-vitro dissolution test, spray dried process yield and flow properties study. Results showed that, globule size of SMEDDS and reconstituted S-SMEDDS was found to be in nanometric range. In-vitro dissolution study showed that enhancement of dissolution of drug from S-SMEDDS than plain diacerin. Solid state characterization such as DSC and XRD studies of S-SMEDDS revealed that diacerein in the S-SMEDDS is in amorphous or molecular dispersion form and passes the accelerated stability testings. Study illustrated that S-SMEDDS can be good drug delivery system to improve the dissolution rate and hence oral bioavailability of diacrein.