Rahul Kumar, Ajay Semalty, Mona Semalty
Department of Pharmaceutical Sciences, H.N.B Garhwal University
Srinagar Garhwal (Uttarakhand)
The study aims to develop anti hyperlipidaemic herbal drug delivery system (Alginate beads) Fenugreek extract. Hyperlipidemia involves abnormally elevated levels of lipids and/or éipoproteins in the blood. It is the most common form of dyslipidemia. Hyperlipidemias are divided in primary and secondary subtypes. Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. Lipid and lipoprotein abnormalities are common in the general population, and are regarded as a modifiable risk factor for cardiovascular disease due to their influence on atherosclerosis. In addition, some forms may predispose to acute pancreatilis.
Alginate beads of fenugreek extract were prepared by solvent injection method using sodium alginate and calcium chloride. Extract was dissolved in sodium alginate solution after that extract- alginate solution was injected drop wise in the calcium chloride solution. Beads were collected and dried. The prepared extract – alginate beads were evaluated for scanning electron microscopy, drug content, drug release and in–vivo evaluation in Swiss albino mice for anti hyperlipidemic activity.
The extract- alginate beads were evaluated for hypolipidaemic activity in mice by treating with high fat diet (400mg/kg) which showed hyperlipidaemic effect. This exhibited a significant anti hyperlipidaemic effect by lowering levels of Lipid profile (cholesterol, triglycerides, LDL, VLDL) and increased levels of HDL in serum.
Key Words: Fenugreek extract, herbal drug delivery system, sodium alginate, calcium chloride, high fat diet.