Tijana Lainović, Larisa Blažić

Faculty of Medicine, School of Dentistry, University of Novi Sad, Novi Sad, Serbia

We are Prof. Dr Larisa Blažić and Tijana Lainović, DMD, research assistant working at Faculty of Medicine, School of Dentistry, University of Novi Sad.

Our main research fields are: dentistry, dental materials science, biomaterials synthesis and characterization, dental nanomaterials, nanotechnological applications in dentistry, biophysics in dentistry, biotechnology. There is a potential for cooperation with the other universities and institutes at the international level, within mutual research projects.>

Nanodentistry, as a term, has been firstly widely used by Freitas R., in JADA, in 2000. Since then, many definitions for this nanotechnology application field were given. Nanodentistry is the science and technology of diagnosing, treating and preventing oral and dental disease, relieving pain, and of preserving and improving dental health, using nanoscale-structured materials. There are numerous nanotechnological applications in dentistry, in investigation, or already in form of commercially available products at the market. There is a wide list of currently or potentially used nanomodified products and procedures in dentistry, and they are briefly listed below.


Operative and restorative dentisty.

  • dental nanocomposites with improved mechanical, chemical and optical properties;
  • biomimetic tooth analogue materials, mimicking enamel and dentin nanometer-scale architecture, and anisotropic nature – leading to minimally invasive tooth removal procedures; 
  • restorative composites with antimicrobial nano-agents;
  • nano fluoride releasing materials.


  • pulp and periodontal tissue healing and regeneration procedures using new active nanobiomaterials for endodontic tissue regenerations.

Hard tissue remineralization and reparation – preventive dentistry:

  • dental caries prevention by nano fluoride-ion releasing materials;
  • dental „sensitive” pastes containing remineralizing nanoparticles;
  • self-assembly peptides for restoring tooth decays;
  • remineralization and healing of dentin hypersensitivity;
  • materials with antimicrobial nanoparticles;
  • plaque monitoring nano-systems.

Endoosseous dental root implants impovements:

  • implant surface nanomodifications for better and faster osseointegration, enabling earlier implant loadings;
  • nano TiO2 coatings for improved implant corrosin resistance.

Bone augmentation, GTR (Guided tissue regeneration), GBR (Guided bone regeneration), GPR (Guided periodontal regeneration):

  • scaffols, membranes, artifical bone foams and injectable systems with nanoparticles for osseoconducting and better quality of osseointegration;
  • nanocarriers with osteogenic growth factors and antibacterial drugs etc.

Nanodiagnostics and nanotreatments:

  • improved oral diagnostic procedures and monitoring tools for health maintenance, enabling earlier desease detection, as well as timely conducted therapeutic procedures.

Oral cancer treatment:

  • Dental local nanocontainers can be placed in oral environment for local drug delivery in order to treat oral cancer or other disease.


  • Dental nanorobots could potentially manipulate periodontal tissues, allowing positioning the teeth to the desired positions.


Seeing all the mentioned possibilities, which are only representatives of current nanodentistry development, it is certain that the nanotechnogical applications in dental biomaterials, tools, and devices will be in a focus of dental research in future years.

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