Formulation and Characterization of Mucoadhesive Nanoparticles of an Antiviral Drug

Ankit Anand Kharia1,2* and Akhlesh Kumar Singhai2,3

1*Oriental College of Pharmacy, Department of Pharmaceutics, Thakral Nagar, Raisen Road Bhopal, Madhya Pradesh, 462021, India; 2Uttarakhand Technical University, Department of Pharmacy, Chandanwadi, Prem Nagar, Sudhowala, Dehradun, Uttarakhand, 248007, India; 3Lakshmi Narayan College of Pharmacy, Department of Pharmaceutics, Raisen Road, Bhopal Madhya Pradesh, 462021, India  

I am working as a associate professor at Oriental College of Pharmacy, Bhopal. My research field or area of interest are nanotechnology, nanoparticles, gastroretention, mucoadhesion, optimization etc. I am interested in research collaborations with research institutes or persons from India and other part of the world.

The objective of this study was formulation and evaluation of mucoadhesive nanoparticles of acyclovir. Nanoparticles were prepared by one step desolvation method by using gelatin as a mucoadhesive polymer. The effects of amount of gelatin and Pluronic F-68 on particle size, polydispersity index, entrapment efficiency, loading efficiency, mucoadhesive strength were studied. The size of all nanoparticulate formulations were in the range of 207.7 to 452.2 nm, polydispersity index in the range of 0.292 to 0.506, entrapment efficiency between 36.29 and 78.11%, loading efficiency between 24.45 and 43.13% and mucoadhesive strength between 6.012 to 10.974 g. Nanoparticulate formulation F4 with 1:2 gelatin and Pluronic F-68 in 1:2 showed satisfactory results i.e. average particle size 207.7 nm, polydispersity index 0.338, entrapment efficiency 54.21%, loading efficiency 43.13% and mucoadhesive strength of 6.012 g. FTIR study concluded that there was no major interaction occurred between the drug and polymers used in the present study.

Keywords: Acyclovir, Mucoadhesion, Gelatin, Nanoparticles.


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