Nanocarriers for Passive and Active Targeting in Liver Cancer
Mohammad Ahmad, Anuradha Mishra and Juber Akhtar
Faculty of Pharmacy, Integral University, Kursi Road-Dasauli, Lucknow-226 026 (India)
Hepatocellular carcinoma (HCC) is regarded as the 5th most common type of cancer and third major cause of cancer-related death worldwide. Nanocarrier systems including liposomes and nanoemulsion are experiencing a very active development and these are highly used drug carriers. Liposomes are usually made of phospholipids molecules that have a head group in addition to a tail group with the ability to entrap hydrophilic drugs in their internal water compartment and hydrophobic drugs in their membrane. These spherical vesicles with a diameters ranging from about 50 to 5000 nm could offer excellent characteristics for active targeting of liver cancer. On the other hand Lipid nanoemulsions are complex, kinetically stable oil-in-water dispersions, homogenized with the help of a surfactant. Nanoemulsions are widely used as drug carriers because they easily incorporate lipophilic agents, prevent the hydrolysis of the bioactive compounds, and reduce side effects of potent agents. Numerous publications and patents being granted on Liposomes and Nanoemulsions nanocarriers reflects its promising application in active targeting of many types of liver cancers.