Nano based strategies to enhance the oral delivery of anti-cancer therapeutics
Usama Ahmad, Abdul Qadir, Md. Faiyazuddin, Juber Akhtar
Faculty of Pharmacy, Integral University, Lucknow, India-226026
Worldwide cancer deaths are predicted to rise from an estimated 8.2 million annually to 13 million per year. It is one the most deadly disease existing today. With the emergence of nanotechnology in medicines during the last decade, there has been a tremendous increase in the use of size reduction strategies to enhance the solubility & bioavailability of many potential anti-cancer chemotherapeutic agents & to provide them a robust strength against physical, chemical & environmental degradation. Nanotechnology serves as targeted drug delivery vehicles, capable of ferrying large doses of chemotherapeutic agents or therapeutic genes into malignant cells while sparing healthy cells, which would greatly reduce or eliminate the often unpalatable side effects that accompany many current cancer therapies. Already research has shown that nanoscale devices such as liposomes, nanoemulsions, dendrimers (spherical, branched polymers), silica-coated micelles, and ceramic nanoparticles can be targeted to cancer cells. The present work focuses on various nanoformulation strategies to enhance the oral delivery of potential anti-cancer agents for effective targeting into malignant cells.