QbD enabled Xanthan gum capped green synthesis of Optimized Gold nanoparticles
Alam Md Sabir1, Salim M.A1, Yadav Ashutosh2, Javed Md Noushad3
1. Luqman College of Pharmacy
2. Fortis healthcare
3. Jamia Hamdard University
During recent years the field of nanotechnology focus on gold nanoparticle which has led to early-phase clinical trials as promising therapeuticals , photothermals, diagnostic, contrast media , radiosensitisers agents. There is also growing interest in utilization of gold nanoparticles as drug delivery of existing drugs especially cytotoxic drugs, to improve its pharmacokinetics parameters by reducing its non-specific side effects and to enable higher dose payload in affected tissues.
Conventional method for synthesis of Gold nanoparticles utilize various chemicals which are very toxic for normal cells which limit its use, so here emphasis are now a day’s towards synthesis of Gold Nanoparticle through green route. Many natural agents however are explored in past as reducing agent including citric acid but these were not only lack in terms of stability but also they can’t hold drug with it so there use as in clinical study are not possible.
Xanthan gum (XG) here selected which have dual role as reducing and stabilizing agent. These gums are also widely use in food, pharmaceutical and cosmetic industries because these are safe for internal consumption due to its high biocompatibility and biodegradability.
In the present study, we explored the potential of XG in the synthesis of gold nanoparticles and effect of various formulation and process variables such as temperature, gum concentration, and gold concentration, are tested using QbD approach for synthesis of optimized Gold Nanoparticles.