Md. Faiyazuddin1,2, R K Khar1, A Bhatnagar3, F J Ahmad1


1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, IND

2Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, IND

3Division of Nuclear Medicine, Institute of Nuclear Medicine & Allied Sciences (INMAS), Delhi-110054, IND

In respiratory pharmaceutics, it is an open challenge to the scientists to cover all possible aspects in designing of stable particles. Particles less than 1 μm possess unique aerosol and deposition effects due to their increased surface for dissolution and improved fluidization for redispersion of drug, tailored release, decreased toxicity and deep targeting capabilities. Various drying operations have been reported in literatures utilized for nanoparticles, but none of them were found relevant as per pharmaceutical demand. The present investigations were undertaken to highlight the issue related to undesired particle growth and to optimize a robust drying method which deliver particles in submicron range. Commonly utilized drying methods like heat, freezing, vacuum, rotary and spray drying have been selected for this study to set their comparative distinction in controlling drug particle size using terbutaline sulfate (TBS) as a model drug. Formulation approaches in the development of stable submicron particles for effective lungs targeting by inhalation route are highlighted here. Also, the potential effect of drying and storage on particle performance is summarized. Also, submicron particles have been estimated in alveolar tissue and bronchioalveolar fluid by UHPLC-ESI-qTOF/MS.

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