"We are working specifically with the reactivity of disulphide bridges in proteins - and we have verified that we can open them with UV light, provided that they are flanked with an aromatic group, eg TRP. In the open reactive state they can react…"
"1.Strong interaction with thiol groups present in cell respiratory enzymes in the microbe cell.
2.Interaction with structural proteins and preferential binding with DNA bases to inhibit replication.
3.Binding of the silver ion to free sulphydryl…"
My research field or area of interest innanotechnology
Nanomedicine, Pancreatic Cancer, Skin Cancer
Anti-cancer and chemo-preventive activity of natural compounds,Identification and characterization of novel therapeutic targets against cancer,Development of novel nano-delivery system to target cancer cells,Nanotoxicology, silver nanoparticles
1. Arora, S., Tyagi, N., Deshmukh S. K., Singh, S., Marimuthu, S., Singh, A.P. (2015). Mission possible: Exploiting nanoways for the development of microRNA-based cancer therapeutics. Journal of Biomedical Nanotechnology (Accepted for publication)
2. Arora, S., Tyagi, N., Bhardwaj, A., Rusu, L., Palanki, R., Vig, K., Singh S.R., Singh A.P., Palanki, S., Miller, M. E., Carter J.E., Singh, S. (2015). Silver nanoparticles protect human keratinocytes against UVB radiation-induced DNA damage and apoptosis: potential for prevention of skin carcinogenesis. Nanomedicine: Nanotechnology, biology and Medicine. 11:1265–1275.
3. Arora, S., Swaminathan, S.K., Kirtane, A., Srivastava, S.K., Bhardwaj, A., Singh, S., Panyam, J., Singh, A.P. (2014). Synthesis, characterization, and evaluation of poly (D, L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy. International Journal of Nanomedicine. 9:2933-42.
4. Arora, S., Bhardwaj, A., Singh, S., Srivastava, S.K., McClellan S., Nirodi C.S., Piazza, G.A., Grizzle W.E., Owen, L, B., Singh, A.P., (2013). An undesired effect of chemotherapy: gemcitabine promotes pancreatic cancer cell invasiveness through ROS-dependent, NF-κB- and HIF-1α-mediated upregulation of CXCR4. Journal of Biological chemistry. 288(29):21197-207.
5. Arora, S., Singh, S., Piazza, G.A., Contreas, C.M., Panyam, J., and Singh, A.P. (2012). Honokiol: a novel natural agent for cancer prevention and therapy. Current Molecular Medicine. 12 (10); 1244-1252.
6. Arora, S., Rajwade, J.M., Paknikar, K.M., (2012). Nanotoxicology and in vitro studies: the need of the hour. Toxicology and applied pharmacology. 258:151-165.
7. Arora, S., Bhardwaj, A., Srivastava, S., Singh, S., McClellan, S., Wang, B & Singh, A.P. (2011). Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS ONE. 6 (6): e21573.
8. Arora, S., Jain, J.,Rajwade, J.M., Paknikar, K.M., (2009). Interactions of silver nanoparticles with primary mouse fibroblast and liver cells. Toxicology and applied pharmacology, 236, 310-318.
10. Khan M.A., Srivastava S.K., Bhardwaj A., Singh S., Arora S., Zubair H., Carter J.E., Singh A.P. (2015). Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications. Oncotarget. (Accepted for publication)
11. Srivastava S.K, Bhardwaj A., Arora S., Tyagi N., Singh A.P., Carter J.E, Scammell J.G, Fodstad Ø, Singh S. (2015). Interleukin-8 is a key mediator of FKBP51-induced melanoma growth, angiogenesis and metastasis. British journal of cancer. 112(11):1772-1781.
12. Srivastava, S.K., Arora, S., Averett, C., Singh, S., Singh, A.P. (2015). Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance. BioMed Research International. 2015,1-9.
14. Bhardwaj, A., Singh, S., Srivastava S.K., Arora, S., Hyde, S.J., Andrews, J., Grizzle, W.E., Singh A.P. (2014). Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model. British journal of cancer. 110 (8), 2000-2010.
15. Srivastava, S.K., Arora, S., Singh, S., Bhardwaj, A., Averett, C., Singh, A.P. (2014). MicroRNAs in Pancreatic Malignancy: Progress and Promises. Cancer Letters. S0304-3835(14)00106-2.
16. Bhardwaj, A., Arora, S., Prajapati, V.K., Singh, S., and Singh, A.P. (2013). Cancer stemness-regulating miRNAs: role, mechanisms and therapeutic potential. Current Drug Targets.14 (10):1175-84.
17. Singh, A.P., Arora,S., Bhardwaj, A., Srivastava, S.K., Kadakia, M.P., Wang, B., Grizzle W.E., Owen, L,B., Singh, S (2012). CXCL12/CXCR4 signaling axis induces SHH expression in pancreatic cancer cells via ERK- and Akt- mediated activation of NF-κB: implications for bidirectional tumor-stromal interactions. Journal of Biological chemistry. 287(46):39115-24.
18. Srivastava S.K., Bhardwaj A., Singh S., Arora S., McClellan S., Grizzle W.E., Reed E., and Singh A.P. (2012). Myb overexpression overrides androgen depletion- induced cell cycle arrest and apoptosis in prostate cancer cells, and confers aggressive malignant traits: potential role in castration-resistance. Carcinogenesis. 33(6):1149-1157.
19. Malhi S.S., Budhiraja A., Arora S., Chaudhari K.R., Nepali K., Kumar R., Sohi H., and Murthy R.S. (2012). Intracellular delivery of redox cycler-doxorubicin to the mitochondria of cancer cell by folate receptor targeted mitocancerotropic liposomes. International Journal of Pharmaceutics. 432(1-2):63-74.
20. Srivastava S., Bhardwaj A., Singh S., Arora S., Wang B., Grizzle W.E., and Singh A.P. (2011). MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells. Carcinogenesis. 32(12):1832-1839.
21. Jain, J., Arora, S., Rajwade J.M., Omray, P., Khandelwal, S., Paknikar K.M., (2009). Silver Nanoparticles in Therapeutics: Development of an Antimicrobial Gel Formulation for Topical Use. Molecular Pharmaceutics, 6 (5), 1388–1401.
22. Kale, S.N., Rajagopal, R., Arora, S., Bhayani, K.R., Rajwade, J.M., Paknikar K.M., kundaliya, D.C., Ogale, S.B., (2007) Microwave response of La0.7Sr0.3MnO3 nanoparticles for heating applications. Journal of Biomedical Nanotechnology. 3, 178-183.
23. Bhayani, K.R., Kale, S.N., Arora, S., Rajagopal, R., Mamgain, H., Kaul-Ghanekar, R., Kundaliya, D.C., Kulkarni, S.D., pasricha, R., Dhole, S.D., Ogale, S.B., Paknikar, K.M., (2007). Protein and polymer immobilized La0.7Sr0.3MnO3 nanoparticles for possible biomedical applications. Nanotechnology.18, 1-7.
24. Kale, S.N., Arora, S., Bhayani, K.R., Paknikar, K.M., Rajagopal, R., Jani, M., Wagh, U.V., Kulkarni, S.D., Ogale, S.B., (2006). Cerium doping and stoichiometry control for biomedical use of La0.7Sr0.3MnO3 nanoparticles: microwave absorption and cytotoxicity study. Nanomedicine: Nanotechnology, biology and Medicine. 2, 217-221.
Researchgroup, Institute, University, School, Company name
USAMCI, Mobile NIPER, Mohali, ISF Moga, ARI Pune
Researchgroup, Institute, Company, University, School webpage
We are working specifically with the reactivity of disulphide bridges in proteins - and we have verified that we can open them with UV light, provided that they are flanked with an aromatic group, eg TRP. In the open reactive state they can react with gold surfaces, or gold nano particles.
As of yet we have not tried Silver, or Aluminum, but we expect Silver to be working well.
It could be interesting to mount antimicrobial peptides onto Silver nanoparticles, and check if their antimicrobial efficiency goes up or not
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