Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo

http://www.futuremedicine.com/doi/abs/10.2217/nnm.11.177

Trinity College Dublin Scientists Establish Link Between Autoimmune Diseases such as Rheumatoid Arthritis and Nanoparticles:

" " The result was clear and convincing: all types of nanoparticles in both the TCD and US study were causing an identical response in human cells and in the lungs of mice, manifesting in the specific transformation of the amino acid arginine into the molecule called citrulline which can lead to the development of autoimmune conditions such as rheumatoid arthritis. " " 

 

" " TCD's Professor Volkov says: "The research establishes a clear link between autoimmune diseases and nanoparticles." " "