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A porcine model of complement activation-related pseudoallergy to nano-pharmaceuticals: Pros and cons of translation to a preclinical safety test

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Pigs provide a sensitive and quantitative animal model of non-IgE-mediated (pseudoallergic) hypersensitivity reactions (HSRs) caused by liposomes and many other nanoparticulate drugs or drug-carrier nanosystems (nanomedicines). The rapidly arising symptoms, including cardiopulmonary, hemodynamic, hematological, blood chemistry and skin changes, resemble the clinical picture in man undergoing infusion reactions to reactogenic nanoparticles. In addition to summarizing the basic features of the pig CARPA model, the review considers some of the advantages and disadvantages of using the model for preclinical evaluation of nanomedicine safety.

A porcine model of complement activation-related pseudoallergy to nano-pharmaceuticals: Pros and cons of translation to a preclinical safety test

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