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with regards,
Ch.L.R.Jaidev.
Who knows about the technical ionization of nanoparticles silver? How they will be ionized when they are put to water without using the electrodes?
2.Interaction with structural proteins and preferential binding with DNA bases to inhibit replication.
3.Binding of the silver ion to free sulphydryl groups in the bacterium or on its surface leading to inactivation of the enzyme phosphomannose Isomerase (essential for biosynthesis of cell wall).
Therefore, it attacks many sites simultaneously and microbes can not get resistant easily against silver.
In case of Viruss e.g. HIV-I, its a site specific (gp 120 protein recepters) and size dependent binding mechanism that inhibits binding of virus to the host cell.
Amod Shepal
Microbiologist,
Pune, India
Thanx for your reply. How can a nanoparticles becomes toxic When if the same is in bulk?
as nanoparticles are smaller, the greater its surface area to volume ratio and higher its chemical reactivity, and biological activity. as greater the chemical reactivity, results increased in production of ROS, including Free radicals- oxidative stress, inflammation, etc... primary mechanism of TOXICITY..
according to sum reports, there are certain nanoparticles tht may move into the sensitive lungs tissues after inhalation, and cause damage tht may leads to chronic breathing problems..
another e.g. is of Carbon Nanotubes, are frequently linked to the asbestos, tht can leads to Mesothelioma, cancer of lining of lungs becoz of asbestos, results observed during experimenting in abdominal cavity of mice using carbon NTs..
your infomration is quiet good. Thank you for participating in the discussion. The one thing that I observed from your views is that the electrostactic attractions between the silver nanopartilces and the P and S atoms might be responsible for the binding. Do you have any information regarding the entrance of silver nanoparticles into the bacteria?
In our culture we have local traditions of wearing silver rings or chains when there is some injures or fever, I would like to ask about wearing the silver rings will affect the bact. or it has to be nano...Regards
silver nanoparticles does not follow any particular pathway or signalling mechanism to get enter the cell.
Silver nanoparticles entrance in cell can be compared with killing somebody with bullet. One possible mechanism could be phagocytosis. ROS can be after effect once SNPs get through the cell as a responce of bacterial cell.