Antimicrobial activity of silver nanoparticles.

Dear members,I saw many articles in newspapers and in net regarding the antimicrobial activity of silver nanoparticles. The nanoparticles are the fascinating things today. How can the silver nanoparticles inhibit or kill the bacteria or virus or even fungi. What is the actual thing that lies behind to work silver nanoparticles as antimicrobial agents. I hope i will get sufficient discussions over this topic.

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  • I am thankfull to everyone who had participated in this discussion by sharing some valuable information. I am also thankfull for the sugessions and expression of thier views on this discussion. With enriched information in mind and safisfaction in heart I would like to close this discussion. I am thankful to Nanopaprika for giving such a wonderful platform to interact with international nanotech research people.

    with regards,
  • dear friends,
    Who knows about the technical ionization of nanoparticles silver? How they will be ionized when they are put to water without using the electrodes?
  • 1.Strong interaction with thiol groups present in cell respiratory enzymes in the microbe cell.
    2.Interaction with structural proteins and preferential binding with DNA bases to inhibit replication.
    3.Binding of the silver ion to free sulphydryl groups in the bacterium or on its surface leading to inactivation of the enzyme phosphomannose Isomerase (essential for biosynthesis of cell wall).
    Therefore, it attacks many sites simultaneously and microbes can not get resistant easily against silver.
  • Hello,
    In case of Viruss e.g. HIV-I, its a site specific (gp 120 protein recepters) and size dependent binding mechanism that inhibits binding of virus to the host cell.

    Amod Shepal
    Pune, India
    • Dear Amod,
      Thanx for your reply. How can a nanoparticles becomes toxic When if the same is in bulk?
      • Hello,
        as nanoparticles are smaller, the greater its surface area to volume ratio and higher its chemical reactivity, and biological activity. as greater the chemical reactivity, results increased in production of ROS, including Free radicals- oxidative stress, inflammation, etc... primary mechanism of TOXICITY..
        according to sum reports, there are certain nanoparticles tht may move into the sensitive lungs tissues after inhalation, and cause damage tht may leads to chronic breathing problems..
        another e.g. is of Carbon Nanotubes, are frequently linked to the asbestos, tht can leads to Mesothelioma, cancer of lining of lungs becoz of asbestos, results observed during experimenting in abdominal cavity of mice using carbon NTs..
  • Silver has good affinity towards sulphur and phosphorus. sulphur is found in most of the proteins and phosphorus is the backbone of DNA. Silver nanoparticles are not antimicrobial rather they are microbialcidal i.e. they do not attack on any specific region rather they can attach anywhere they find P & S, therby checking the metabolic pathway or transcription.
    • Dear Mr. Vyom Parashar,
      your infomration is quiet good. Thank you for participating in the discussion. The one thing that I observed from your views is that the electrostactic attractions between the silver nanopartilces and the P and S atoms might be responsible for the binding. Do you have any information regarding the entrance of silver nanoparticles into the bacteria?
      • Dear All,
        In our culture we have local traditions of wearing silver rings or chains when there is some injures or fever, I would like to ask about wearing the silver rings will affect the bact. or it has to be nano...Regards
      • Dear Mr.Jaidev

        silver nanoparticles does not follow any particular pathway or signalling mechanism to get enter the cell.
        Silver nanoparticles entrance in cell can be compared with killing somebody with bullet. One possible mechanism could be phagocytosis. ROS can be after effect once SNPs get through the cell as a responce of bacterial cell.
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