Gender
Female
Location
Salem, Tamilnadu
Birthday:
March 19
I am...
Biologist
My research field or area of interest innanotechnology
Nanomedicin
Interest in...
Breast cancer is the most common invasive cancer among women leading to 1.15 million deaths every year worldwide. As the prevalence of cancer persists, the development of innovative and more advanced diagnostic and therapeutic tools remains a priority in research. The RNAi technology has recently emerged as potential diagnostic and therapeutic tool for cancer. RNAi is performing an imperative role in normal cell development and differentiation. Yet in cancer cells, it has a prevailing mechanism in the regulation of gene expression. Harnessing RNAi to silence genes involved in breast cancer holds promise for the development of a new class of therapeutics. Although, the biocompatibility, stability, degradation in circulation, endosomal escape and delivery efficiency, targeting, toxicity and off-target effects are the rationale, in the proposed research we plan to avail the subtype of RNA molecules to interfere with and silence the E2F3/Akt/Mdm2/AR transcription factor signaling circuit. However, researchers have encountered difficulties in administering siRNA, as the molecules must penetrate cells in therapeutically effective concentrations, which in turn require structural modifications and suitable carrier to not only deliver siRNA but also protect from other exo/endogenous factors for effective functioning of SiRNA (E2F3). Hence, in the proposed investigation absolutely matches with my expertise and deep interest in RNAi that will be complemented by expertise at RMIT University, Australia in the areas of nanotechnology based RNAi delivery system. The current project will help me to learn Nano based RNAi technology; build up long-lasting research collaboration and a path forward to generate drug delivery and therapeutic tool for breast cancer. As this proposal falls in the category of breast cancer it will be of major significance for both India and Australia.
Publication list
1. Vimala, K., Sundarraj, S., Paulpandi, M., Kannan. S. (2014) Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma. Process Biochemistry 49: 160–172. (Impact factor: 2.516) 2. Vimala, K.., Sundarraj, S., Sujitha, M.V., Kannan S. (2012) Curtailing Overexpression of E2F3 in Breast Cancer Using siRNA (E2F3)-Based Gene Silencing. Archives of Medical Research 43: 415 - 422. (Impact factor: 2.41) 3. Vimala, K., Kannan. S. (2014) Codelivery of E2F3 siRNA and doxorubicin by zinc Oxide nanorods (ZnONRs) promoted breast tumor Suppression. Annals of Oncology 25 (Supplement 1): i25–i27, 2014. (Impact factor: 6.2) 4. K. Shanthi, K.Vimala, D. Gopi, S. Kannan. 2015. Fabrication of pH Responsive DOX Conjugated PEGylated Palladium Nanoparticle Mediated Drug Delivery System: an in vitro and in vivo Evaluation. RSC Advance, 5, 44998-45014. (Impact factor: 3.708) 5. Sundarraj, S., Thangam, R., Sujitha, M.V., Vimala, K., Kannan. S. (2014) Ligand-conjugated mesoporous silica nanorattles based on enzyme targeted prodrug delivery system for effective lung cancer therapy. Toxicology and Applied Pharmacology 275: 232–243. (Impact factor: 3.975) 6. Praseeja Cheruparambath, K.Vimala, A. Asaikkutti, K. Rukhsana and E.M. Manogem (2015) In Vitro Antioxidant Activity Of Extract From Dahlia X Hybrida Species. International Journal of Pure and Applied Zoology Volume 3: 113-118. 7. Vimala, K., Sundarraj, S., Paulpandi, M., Kannan, S. (2014) Synergistic Effect of Chemo-Photothermal for Breast Cancer Therapy Using Folic Acid (FA) modified Poly Ethylene Glycol (PEG) Coated ZnO Nanosheet. Journal of Photochemistry and Photobiology B: Biology (Under Review). (Impact factor: 3.14) 8. Vimala, K., Kannan, S. (2014) Synchronized Delivery of siRNA and an Anti Cancer Drug through “Two-in-One” ZnO Nanoparticles Promotes Synergistic Tumor Suppression. Journal of Translational Research (Under Review). (Impact factor: 4.044)
Researchgroup, Institute, University, School, Company name
proteomics and mol. Bio., Periyar University, School of Lifesciences, Periyar University
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