Gender
Female
Location
patna
Birthday:
February 12
I am...
Biologist
My research field or area of interest innanotechnology
Research summary I have gathered my research experience in the field of supramolecular DNA assembly where I had applied the basic principle of chemistry and biology to device nanoscale materials. I had used the synergistic properties of nucleic acids and synthetic molecules to address challenges of precise molecular patterning, chemical construction for DNA based therapeutic use and protection of DNA themselves. I have created novel two and three dimensional superstructures in the nanoscale by covalent conjugation of DNA with organic molecules like melamine, porphyrin and triptycenetripropiolic acid and their subsequent self-assembly. I have established the construction of linear and network type supramolecular DNA structures from melamine-DNA conjugates. Melamine is an organic molecule and their dendrimer and other conjugates are recently used as drug delivery vehicle and transfection. I have designed the DNA- quantum dot array where melamine –DNA conjugates used as linker. This newly constructed array can be used in electronics, optics and sensing applications. I have also constructed nanofibers from the zinc protoporphyrin IX templated assemblies of triptycene-DNA building blocks.This biocompatible novel nanostructure has superior and coherent reactive oxygen species generation properties that could be explored as an effective tool in photodynamic therapy (PDT) as well as photo catalytic reactions and others. On the other hand, I have also designed an antimicrobial film from self assembly of covalent conjugates DNA porphyrin, this film has high efficancy over free porphyrin film. Additionally, I have also studied the supramolecular interaction of DNA with heterocyclic, planar rigid, newly synthesised organic and inorganic molecules, carbon nanomaterials and polymeric materials. The recognition and supramolecular interactions of DNA with the functional elements of synthetic organic and inorganic molecules play a vital role in drug designing, delivery, mechanism of action and other biomedical applications. I have created a polyplex by the interaction of tyrosine amino acid polymer with genomic DNA. I also have highlighted the effect of carbon nanomaterials on extracellular DNA repairing process.
Interest in...
Nanobiotechnology
Publication list
1.Synthesis and characterization of a biocompatible monotyrosine-based polymer and its interaction with DNA. Radhika Mehta, Rina Kumari, Prolay Das and Anil K. Bhowmick, Journal of Materials Chemistry B, 2014, 2, 6236-6248 2.Binding and Interaction of Di- and Tri-Substituted Organometallic Triptycene Palladium Complexes with DNA. Rina Kumari, Sourav Bhowmick, Neeladri Das and Prolay Das, Journal of Biological Inorganic Chemistry, 2014, 19, 1221-1232 3.Synthesis, characterization and DNA interaction studies of new triptycene derivatives, Sourav Chakraborty, Snehasish Mondal, Rina Kumari, Sourav Bhowmick, Prolay Das, and Neeladri Das, Beilstein Journal of Organic Chemistry, 2014, 10, 1290–1298. 4.DNA-Melamine Hybrid molecules: from Self-Assembly to Nanostructures, Rina Kumari, Shib Shankar Banerjee, Anil K. Bhowmick and Prolay Das, Beilstein Journal of Nanotechnology, 2015, 6, 1432–1438. 5.Melamine-DNA Encoded Periodicity of Quantum dot Arrays, Seema Singh, Rina Kumari, Anirban Chakraborty, Sahid Hussain, Manoj K. Singh, Prolay Das, Journal of Colloid and Interface Science, 2015, 461, 45-49 6.Impeded repair of abasic site damaged lesions in DNA adsorbed over functionalized multiwalled carbon nanotube and graphene oxide, Rina kumari,Titash Mondal,Prolay Das and Anil K. Bhowmick. Mutation research/Genetic toxicology and environmental mutagenesis, 2016, 803-804,39–46 7.Hierarchical Coassembly of DNA-Triptycene Hybrid Molecular Building Blocks and Zn PpIX Rina Kumari,Sumit Singh, Mohan Monisha, Sourav Bhowmick, Anindya Roy, Neeladri Das, and Prolay Das Beilstein Journal of Nanotechnology, 2016, 7, 697-707. Conference Presentations: 1. DNA-Melamine Hybrid molecules: From Self-Assembly to Nanostructures, Recent developments in chemical science & technology, March 15-16, 2014, NIT Rourkela, India. 2. Coherent generation of ROS from DNA-Porphyrin hybrid molecular building blocks, 3rd International Conference on Biological, Chemical and Environmental Sciences (BCES-2015), Sept. 21-22, 2015 Kuala Lumpur, Malaysia. 3. Constraint in repair process of abasic site damaged lesions in DNA adsorbed over Functionalized carbon nanomaterials, National Seminar on “Environmental Pollutant: Safety Measure and Management” Dec. 5-6, 2015 Magadh Mahila College, Patna University, Patna, India. 4. DNA-triptycene hybrid scaffold for ZnPP IX: Hierarchial coassembly and photocatalytic activity 1st international conference on Human implications of Biotechnology(ICHIB-2016), Feb 12-14 2016, Central university of south bihar, Patna, India.
Researchgroup, Institute, University, School, Company name
Dr.Prolay Das research group IIT Patna
Researchgroup, Institute, Company, University, School webpage
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