Gender
Male
Location
Lucknow
Birthday:
October 3
I am...
Student
My research field or area of interest innanotechnology
During my Ph.D. program I worked on a research project aimed to explore the applicability of nanoparticles and other nano formulations as adjunct therapy with contemporary treatment. My Ph.D work was focused on the drug delivery of Arteether by oral route in the condition of multi drug resistant malaria. I have developed various formulations and evaluated them in cell lines and animal model of malaria. It involves formulation development, physiochemical characterization, in-vitro release and stability studies, in vitro efficacy studies, pharmacokinetic parameters, host pathogen interaction and studies on malaria infected animal models. In other projects, I have developed nanoparticles containing anti-leishmania drugs and evaluated their efficacy, toxicity and innate immune response in cells lines and in animal models i.e. mice and whistar rats. I have also evaluated pharmacokinetic bio-distribution and toxicity studies in rats. In addition; I have also prepared nitric oxide releasing, Amphotericin-B and Doxorubicin containing Nanoparticles for treatment of leishmaniasis. My studies are further elaborated on the nanoparticles to target colon cancer and made attempt to design receptor associated drug delivery system for its targeting.
Interest in...
With this background and training I am confident that I am well equipped to take the next challenge of being a productive Post-Doctoral fellow in any laboratory of drug delivery.
Publication list
1. Dwivedi P, Khatik R, Khandelwal K, et al. Pharmacokinetics study of arteether loaded solid lipid nanoparticles: An improved oral bioavailability in rats. International Journal of Pharmaceutics 2014;466(1–2):321-7. 2. Dwivedi P, Kansal S, Sharma M, et al. Exploiting 4-sulphate N-acetyl galactosamine decorated gelatin nanoparticles for effective targeting to professional phagocytes in vitro and in vivo. J Drug Target 2012;20(10):883-96. 3. Khatik R, Dwivedi P, Khare P, et al. Development of targeted 1, 2-diacyl-sn-glycero-3-phospho-l-serine-coated gelatin nanoparticles loaded with amphotericin B for improved in vitro and in vivo effect in leishmaniasis. Expert Opin Drug Deliv 2014;7:7. 4. Dwivedi P, Khatik R, Khandelwal K, et al. Preparation and Characterization of Solid Lipid Nanoparticles of Antimalarial Drug Arteether for Oral Administration. Journal of Biomaterials and Tissue Engineering 2014;4(2):133-7. 5. Khatik R, Dwivedi P, Upadhyay M, et al. Toxicological Evaluation and Targeting Tumor Cells Through Folic Acid Modified Guar Gum Nanoparticles of Curcumin. Journal of Biomaterials and Tissue Engineering 2014;4(2):143-9. 6. Sharma M, Malik R, Verma A, Dwivedi P, et al. Folic acid conjugated guar gum nanoparticles for targeting methotrexate to colon cancer. J Biomed Nanotechnol 2013;9(1):96-106. 7. Singodia D, Kansal S, Verma A, Dwivedi P, et al. Development of Nevirapine Loaded Novel Surfactant Free Polymeric Emulsion and Investigations for Its Suitability as Drug Delivery Vehicle. Journal of Bionanoscience 2010;4(1-2):66-73. 8. Kansal S, Tandon R, Dwivedi P, et al. Development of nanocapsules bearing doxorubicin for macrophage targeting through the phosphatidylserine ligand: a system for intervention in visceral leishmaniasis. J Antimicrob Chemother 2012;67(11):2650-60. 9. Shukla P, Gupta G, Singodia D, Verama A, Dwivedi P, et al. Emerging trend in nano-engineered polyelectrolyte-based surrogate carriers for delivery of bioactives. Expert Opin Drug Deliv 2010;7(9):993-1011. 10. Khandelwal K, Pachauri SD, Zaidi S, Dwivedi P, et al. Assay method for quality control and stability studies of a new antimalarial agent (CDRI 99/411). Journal of Pharmaceutical Analysis 2013;3(5):335-40. 11. Gupta PK, Jaiswal AK, Kumar V, Dwivedi P, et al. Covalent Functionalized Self-Assembled Lipo-Polymerosome Bearing Amphotericin B for Better Management of Leishmaniasis and Its Toxicity Evaluation. Mol Pharm 2014;19:19. 12. Tripathi P, Verma A, Dwivedi P, Sharma D, Kumar V, et al. Formulation and Characterization of Amphotericin B Loaded Nanostructured Lipid Carriers Using Microfluidizer J. Biomater. Tissue Eng. 4, 194-197 (2014) 13. R Shukla, J Kumar, P Dwivedi, P Gatla, PR Mishra. Microparticles of Diethylcarbamazine Citrate for the Treatment of Lymphatic Filariasis. Asian Journal of Chemistry 25, S302-S304 14. Khandelwal K, Pachauri S D, Tiwari T, Pandey R R, Ahmed H, Dwivedi P, et al. Assay Method for Quality Control and Stability Studies of a New Antidiabetic Agent (S-001-469). Journal of Biomaterials and Tissue Engineering ACCEPTED MANUSCRIPT: 1. Gupta V, Singh S, Srivastav M, Ahmad H, Pachauri S, Khandelwal K, Dwivedi P, Dwivedi A. Effect of polydimethyl siloxane and ethylcellulose on in-vitro permeation of centchroman from its transdermal patches. Drug delivery. 2. Gupta V, Singh S, Srivastava M, Ahmad H, Pachauri S D, Khandelwal K, Dwivedi P and Dwivedi A. Preparation and characterization of depot injectable microspheres of centchroman using ethyl cellulose. Journal of Biomaterials and Tissue Engineering COMMUNICATED MANUSCRIPT: 1. Dwivedi P, Khatik R, Khandelwal K, et al. Nano-Areether effectively cure multidrug resistant malaria by improving oral bioavailability with reduced toxicity. Expert Opin Drug Deliv. 2. . Dwivedi P, Khatik R, Chaurvedi P, et al. Nano structured nontoxic Arteether formulation and its pharmacokinetics by LC-MS: An improved oral multi drug resistant malaria chemotherapy Expert Opin Drug Deliv.
Researchgroup, Institute, University, School, Company name
CSIR-Central Drug Research Institute
The network creator will send periodical messages to members - you below to allow us to email you
yes
