Gender

Male

Location

Gyeongnam Jinju

Birthday:

June 12

I am...

Biologist

My research field or area of interest innanotechnology

I did my PhD in Neuroscience title “Neuroprotective Effects against ethanol induced modulation of siRNA-Mediated GABAB1 Receptor and apoptotic neurodegeneration in developing rat brain” and my research project was based on downstream signaling and role of GABAB1R upon acute and chronic ethanol effect of maternal epileptic seizure on apoptotic neuronal death, modulation of GABAB1R, and its effect on further downstream signaling like protein kinase A-α (PKA) and p-CREB expression in prenatal and developing rat brain upon transfected and non transfected condition, where, GABAB1R was knocked down using GABAB1RsiRNA and using different molecular and behavioural techniques such as Western blot, PCR, Immunohistochemistry, Immunofluorescence, Confocal microscopy, Transmission electron microscope, Development of different types of normal and cancer cell lines, and primary neuronal cell culturing, MTT assay, Fluoro Jade-B, Propidium Iodide staining for identification of apoptotic and necrotic cell, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Electron microscopy, Flow cytometer analysis (Becton Dickinson, San Jose, CA, USA), ATP and PKA detection assay, Electroencephalography (EEG) by using Laxtha EEG-monitoring device. Presently I am working on neuroprotective effect of some natural compound against epileptic seizure and other neurodegenerative disease due to exposure of alcohol during early development of fetal brain.

Interest in...

Use of Nano particles as a neuroprotective agents against ethanol induced apoptotic neurodegneration in developing rat barin. Use of Nano particles as a durg delevery models of rat brain against differents insults.

Publication list

1. Ullah N., Naseer M.I., Lee H.Y, Ullah I, Kim. M.O. Nicotinamide Protects against Anticancer drug-induced Apoptotic Neurodegeneration in the Developing Rat Brain. (Submitted 2010 Jan 23 Neurobiology of Disease). 2. Mohsin Shah, Muhammad Imran Naseer, Mun Hwan Choi, Myeong Ok Kim and Sung Chul Yoon. Amphiphilic copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation. (Submitted 30 December 2009 Nanotechnology) 3. Muhammad Imran Naseer, Hassan Zubair, Najeebullah, Ikramullah, Mukhtiar Hassan, Hae Young lee and Myeong Ok Kim. Phorbol myristate acetate (PMA) induced megakaryocytic differentiation of K562 cells from human chronic myelogenous leukaemia patient. (Under revision process Pakistan Journal of Medical Science 14-1-2010). 4. Muhammad Imran Naseer, Najeebullah, Ikramullah and Myeong Ok Kim. Neuroprotective Effect of Vitamin C against Ethanol and PTZ-Induced Apoptotic Neurodegeneration in Prenatal Rat Hippocampal Neurons. (Under Revision Process Alcohol Clin Exp Res). 5. Muhammad Imran Naseer, Myeong Ok Kim. siRNA-mediated GABAB receptor at early fetal rat brain upon acute and chronic ethanol exposure: Down regulation of PKA and p-CREB expression. (Submitted in Synapse 2010 Jan. 23). 6. Hae Young Lee, Muhammad Imran Naseer, Myeong Ok Kim. Time-dependent effect of ethanol on GnRH and GnRH receptor mRNA expression in hypothalamus and testis of adult and pubertal rat. (Neuroscience Letter Accepted 2010 Jan. 4). 7. Muhammad Imran Naseer, Hae Young Lee and Myeong Ok Kim. Neuroprotective effect of vitamin C against the ethanol and nicotine modulation of GABAB receptor and PKA-α expression in prenatal rat brain. (Accepted Synapse 08 Oct. 2009). 8. Muhammad Imran Naseer, Najeebullah, Ikramullah, Hassan Zubair, Mukhtiar Hassan and Myeong Ok Kim. Vitamin C protects ethanol induced apoptotic neurodegeneration in postnatal rat brain. Pakistan J of Med Science 2009, Part 1, Vol. 25 (5) 718-722. 9. Muhammad Imran Naseer, Hay young Lee, Najeeb Ullah, Ikram Ullah and Myeong Ok Kim. Ethanol and PTZ modulates siRNA-mediated GABAB1 receptor: Down regulation of intracellular pathway in prenatal rat cortical and hippocampal neurons. Synapse (Synapse 64:181-190, 2010). 10. Muhammad Imran Naseer, Li Shupeng, Myeong ok Kim. Maternal epileptic seizure induced by Pentylenetetrazol: Apoptotic neurodegeneration and decreased GABAB1 receptor expression in prenatal rat brain. Molecular Brain June 22 2009, 2:20. 11. Muhammad Imran Naseer, Hassan Zubair, Ikram Ullah, Myeong Ok Kim, Effect of Fetal Calf Serum on Cellular Proliferation of Mouse Y1 Adrenocortical Cells in vitro. Pakistan J of Med Science 2009, Part II Vol. 25 (3) 500-504. 12. Nibedita Naha, Hae Young Lee, Muhammad Imran Naseer, Tae Ju Park, Myeong Ok Kim. Ethanol inhibited apoptosis-related RNA binding protein, Napor-3 gene expression in the prenatal rat brain. Med Sci Monit. 2009 Jan; 15(1):BR6-12. 13. Lee HY, Nibedita N, M.I. Naseer. KIM MO. In-vivo and in-vitro ethanol exposure in prenatal rat brain: GABAB receptor modulation on dopamine D1 receptor and protein kinase A. Synapse 2008 May: 62:534-543. 14. A. Gul, M.J. Hassan, S. Mahmood, M. I. Naseer, N. Muhammad, M. A. Rafiq, M. Ansar, M. S. Chishti, G. Ali, W. Ahmad, “ Genetic Studies of Autosomal recessive primary microcephaly in 33 Pakistani families: Novel sequence variant in ASPM gene. Neurogenetics 2006 May; 7(2):105-110.

Researchgroup, Institute, University, School, Company name

Gyeongsang National University Neuroscience lab and Nano-Biomaterials Science Laboratory, Division of Applied Life Sciences (BK21), Graduate School and Environmental Biotechnology National Core Research Center,

Researchgroup, Institute, Company, University, School webpage

https://www.gsnu.ac.kr

The network creator will send periodical messages to members - you below to allow us to email you

yes