Gender

Male

Location

Nottingham

Birthday:

July 6

I am...

Chemist, Physicist, Biologist, Doctor, User of nanotechnology products

My research field or area of interest innanotechnology

I expertise in the nanoscale and microscale characterization of materials such as biopharmaceuticals, biomaterials (proteins and antibodies) and other advanced materials such as dendrons. Analyses involve particle size characterization, imaging, evaulation of secondary structure, thermal stability, crystallanity/amorphicity, porocity, flakiness and antigen-binding strength of proteins. I have comprehensively screened the effect of the process of lyophilization on ferrtin/polyclonal IgG antibody alone and in conjugation with different lyoprotectants, in an effort to overcome aggregation, so that the therapeutic efficiency and shelf life of protein based biopharmaceuticals could be improved. I do possess significant amount of an experience in the measurement of bio-molecular interaction forces at the single molecule level (e.g. for streptavidin-biotin interaction and DNA oligonucleotides), and specifically how these are influenced by nanometre scale changes in the chemistry employed for surface attachment of the involved molecules ? These investigations provide a new insight into the effect of temperature on single molecule force spectroscopy data and the opportunities presented by a novel dendron based immobilization strategy.

Interest in...

Research Interests Nanoscience and Nanotechnology (such as Nanomedicine) Advanced and targeted drug delivery systems Biopharmaceuticals: their development; formulation and physicochemical characterization Regenerative medicine: Sem cells (Human embryonic etc) for cardiac, lung, bone and limb regeneration) Cell therapy: Application of stem cell technologies to in vitro tissue production and the generation of specific cell types for therapeutic use. Nanoscale screening methods for investigating protein/cellular aggregation Molecular cancer therapeutics: Monoclonal antibody therapeutics for different forms of cancer/tumours. Biomaterial characterization, Bio-engineering such as cell and tissue engineering Development of advanced nanomaterials with new/enhanced functionality (therapeutic, electrical, optical, mechanical and thermal).

Researchgroup, Institute, University, School, Company name

LBSA, University of Nottingham

Researchgroup, Institute, Company, University, School webpage

https://www.nottingham.ac.uk/pharmacy/research/lbsa/researchstudents(lbsa)/mudasirlone.aspx

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