Gender

Male

Location

Duarte, CA

Birthday:

October 28

I am...

Doctor

My research field or area of interest innanotechnology

DNA delivery; RNA delivery; antiviral research

Interest in...

gene therapy of HIV-1

Publication list

SELECTED PEER-REVIEWED PUBLICATIONS from 154 peer-reviewed papers-- 1. Li MJ, Bauer G, Michienzi A, et.al. Inhibition of HIV-1 infection by lentiviral vectors expressing Pol III-promoted anti-HIV RNAs. Mol Ther 2003;8(2):196-206. PMID: 12907142. 2. Krishnan A, Molina A, Zaia J, et. al. Durable remissions with autologous stem cell transplantation for high-risk HIV-associated lymphomas. Blood 2005;105(2):874-8. PMID: 15388574. 3. Yam P, Jensen M, Akkina R, Anderson J, Villacres MC, Wu J, Zaia JA, Yee JK. Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Mol Ther 2006;14(2):236-44. PMID: 16647299. 4. Lo HL, Chang T, Yam P, Marcovecchio PM, Li S, Zaia JA, Yee JK. Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters. Gene Ther 2007;14(21):1503-12. PMID: 17805304. 5. Anderson J, Li MJ, Palmer B, Remling L, Li S, Yam P, Yee JK, Rossi J, Zaia J, Akkina R. Safety and efficacy of a lentiviral vector containing three anti-HIV genes--CCR5 ribozyme, tat-rev siRNA, and TAR decoy--in SCID-hu mouse-derived T cells. Mol Ther 2007;15(6):1182-8. PMID: 17406343. 6. Zhou, J., Li, H., Li, S., Zaia, J. and Rossi, J.J. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther 2008 16(8): 1481– 489. PMCID: PMC2727148 7. DiGiusto DL, Krishnan A, Li L, et al, Zaia JA. RNA-based gene therapy for HIV with lentiviral vector-modified CD34(+) cells in patients undergoing transplantation for AIDS-related lymphoma. Sci Transl Med 2010;2(36):1-8. PMCID: 3130552 8. Krishnan A, Palmer JM, Zaia JA, Tsai NC, Alvarnas J, Forman SJ. HIV status does not affect the outcome of autologous stem cell transplantation (ASCT) for non-Hodgkin lymphoma (NHL). Biol Blood Marrow Transplant 2010;16(9):1302-8. PMCID: PMC2916976 9. Hutter G, Zaia JA. Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus: the experiences of more than 25 years. Clin Exp Immunol 2011;163(3):284-95. PMCID: 3048611 10. Guerrero, A., Riddell, S.R., Storek, J., Stevens-Ayers, T., Storer, B., Zaia, J.A., et. al, M. Cytomegalovirus Viral Load and Virus-Specific Immune Reconstitution after Peripheral Blood Stem Cell versus Bone Marrow Transplantation. Biology of Blood and Marrow Transplantation, 2012 18: 66-75. PMCID: PMC3237869 11. Burnett JC, Zaia JA, Rossi JJ. Creating genetic resistance to HIV. Curr Opin Immunol 2012;24:625 PMCID: 3478429 12. Behrendt CE, Nakamura R, Forman SJ, Zaia JA. Donor killer immunoglobulin-like receptor genes and reactivation of cytomegalovirus after HLA-matched hematopoietic stem-cell transplantation: HLA-C allotype is an essential cofactor. Frontiers in Immunology 2013;4. PMCID:3578282 13. Petz, L.D., Redei, I., Bryson, Y., et.al. Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections. Biology of Blood and Marrow Transplantation 2013; 19:393-397. PMID: 23089564 14. Li L, Krymskaya L, Wang J, et. al.. Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger Nucleases. Mol. Ther., 2013 Jun;21(6):1259-69. PMCID: 677314 15. Deeks, S.G., Autran, B., Berkhout, B., Benkirane, et. Al. Towards an HIV cure: a global scientific strategy. Nat Rev Immunol 2012; 12:607-614. PMID: 22814509 16. Cillo AR, Krishnan A, Mitsuyasu RT, McMahon DK, Li S, Rossi JJ, et al. Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma. J Acquir Immune Defic Syndr. 2013;63(4):438-41. PMCID: 3699958

Researchgroup, Institute, University, School, Company name

Beckman Research Instititue City of Hope

Researchgroup, Institute, Company, University, School webpage

https://www.cityofhope.org/people/zaia-john

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