Gender

Male

Location

Ramat Gan

I am...

Chemist

My research field or area of interest innanotechnology

Nano Biotechnology, development biologic high throughput screening technologies NOn viral gene delivery

Interest in...

medicinal chemistry, screening, combinatorial chemistry, targeting, non viral gene delivery

Publication list

1. Davidov, G., Mozes, T., Khandadash, R. and Byk, G. Versatile methods for synthesizing acyl-tetramic acids peptide analogs. JOURNAL OF PEPTIDE SCIENCE (2008), 14(8) Suppl. S, 59. 2. Khandadash, R., Partouche, S., Margel, S. and Byk, G. Micron-sized monodispersed polystyrene for synthesis, tagging and biological screening of small molecules. JOURNAL OF PEPTIDE SCIENCE (2008) 14 (8) Suppl. S, 139 3. Gerardo Byk, Mirit Cohen-Ohana and Daniel Reichman. Fast and Versatile Microwave-Assisted Intramolecular Heck Reaction in Peptide Macrocyclization Using Microwave Energy. Biopolymers 2006, 81, 274-282. 4. Gerardo Byk and Eihab Kabha. A Solid-Supported Stereoselective Multicomponenent Reaction: One-Pot Generation of Three Asymmetric carbons. SYNLETT, 2006, 5, 747-749. 5. Gerardo Byk, David Visnovezky and Daniel Raichman. Fast and Versatile Backbone Modifications and Peptide Macrocyclization Using Microwave Energy. Biopolymers Pept. Sci. 2005, 80, 531. 6. Gerardo Byk, Tamar Tennenbaum, Shlomo Margel and Shirly Partush. Towards in vivo screening of small molecules: Micron sized monodispersed polystyrene for synthesis, tagging and biological screening of small molecules. Biopolymers Pept. Sci. 2005, 80, 597-598. 7. Julia Mazar, Boris Rogachev, Gad Shaked, Nadav Y. Ziv, David Czeiger,Cidio Chaimovitz, Moshe Zlotnik, Igor Mukmenev,Gerardo Byk and Amos Douvdevani. Involvement of Adenosine in the Anti-inflammatory Action of Ketamine. Anesthesiology (2005)102(6), 1174-1181. 8. Gerardo Byk and Eihab Kabha. Anomalous regiselective MCR4 Biginelli reaction II: One pot parallel synthesis of spiro heterobicyclic aliphatic rings. Journal of Combinatorial Chemistry (2004), 6(4), 596-603. 9. Alexander Aizikovich, Vladimir Kuznetsov, Sofia Gorohovsky, Amalia Levy, Simha Meir, Gerardo Byk and Garry GellermanA new application of diphenylphosphorylazide (DPPA) reagent: convenient transformations of quinolin-4-one, pyridin-4-one and quinazolin-4-one derivatives into 4-azido and 4-amino counterparts. Tetrahedron Lett.,(2004) 45, 4241-4243 10. Vladimir Kuznetsov, Sofia Gorohovsky, Amalia Levy, Simcha Meir, Vladimir Shkoulev, Naim Menashe, Moshe Greenwald, Alexander Aizikovich, Dror Ofer, Gerardo Byk and Garry Gellerman. Approaches for introducing high molecular diversity in scaffolds: Fast Parallel Synthesis of Highly Substituted 1H-quinolin-4-one Libraries. Molecular Diversity, (2004), 8(4), 437-448. 11. Gerardo Byk and Eihab Kabha: Regioselective MCR4 reaction: One pot synthesis of spiro heterobicyclic aliphatic rings generated from natural amino acids. Biopolymers, 71(3), 235 (2003) 12. Gerardo Byk, Elisha Haas, Varda Itah and Inbar Rofman. A versatile method for fast and selective introduction of multiple probes into peptides using solid phase synthesis. Applications to biophysical models. Biopolymers 71(3), 470 (2003). 13. Tom Einbinder, Yuval Sufaro, Igor Yusim, Gerardo Byk, Jutta Passlick-Deetjen, Cidio Chaimovitz and Amos Douvdevani: Correction of anemia in uremic mice by genetically modified peritoneal mesothelial cells. Kidney International, Vol. 63 (2003), 2103-2112 14. Sofia Gorohovsky, Simha Meir, Vladimir Shkoulev, Gerardo Byk and Garry Gellerman: A Facile Two-step Synthesis of Novel ring-A double substituted Tryptophan Building Blocks for Combinatorial Chemistry. SYNLETT 10, 1411-1414 (2003) 15. Francoise Leclercq , Mirit Cohen-Ohana, Nathalie Mignet , Andrea Sbarbati,Jean Herscovici, Daniel Scherman and Gerardo Byk : Design, Synthesis and Evaluation of Gadolinium Cationic Lipids As Tools for Biodistribution Studies of Gene Delivery Complexes. Bioconjugate Chem. 14, 112-119 (2003). 16. Nathalie Mignet, Gerardo Byk, Barbara Wetzer and Daniel Scherman. DNA complexes with reducible cationic lipid for gene transfer. Methods in Enzymology 373, 357-69, (2003) 17. Gerardo Byk : Cationic Lipid Based Gene Delivery, in : Pharmaceutical Perspectives of Nucleic Acid Based Therapy. Edited by Ram I. Mahato and Sung Wan Kim Part 3(15), pg 302-333 (2002). 18. Carriere, Marie; Tranchant, Isabelle; Niore, Pierre-Antoine; Byk, Gerardo; Mignet, Nathalie; Escriou, Virginie; Scherman, Daniel; Herscovici, Jean. Optimization of cationic lipid mediated gene transfer: structure-function, physico-chemical, and cellular studies. Journal of Liposome Research 12(1 & 2), 95-106, (2002) 19. Marks, Vered; Gottlieb, Hugo E.; Melman, Artem; Byk, Gerardo; Cohen, Shmuel; Biali, Silvio E. Journal of Organic Chemistry, (2001) 66(20), 6711-6718: Polyethylated Aromatic Rings: Conformation and Rotational Barriers of 1,2,3,4,5,6,7,8-Octaethylanthracene, 1,2,3,4,6,7,8-Heptaethylfluorene, and 1,2,3,4,5,6,7,8-Octaethylfluorene. 20. Wetzer, Barbara; Byk, Gerardo; Frederic, Marc; Airiau, Marc; Blanche, Francis; Pitard, Bruno; Scherman, Daniel. Reducible cationic lipids for gene transfer. Biochem. J. (2001), 356(3), 747-756. 21. Raspaud, Eric; Pitard, Bruno; Durand, Dominique; Aguerre-Chariol, Olivier; Pelta, Juan; Byk, Gerardo; Scherman, Daniel; Livolant, Francoise. Polymorphism of DNA/Multi-cationic Lipid Complexes Driven by Temperature and Salts. J. Phys. Chem. B (2001), 105(22), 5291-5297. 22. Byk, Gerardo; Gottlieb, Hugo E.; Herscovici, Jean; Mirkin, Fiana. New Regioselective Multicomponent Reaction: One Pot Synthesis of Spiro Heterobicyclic Aliphatic Rings J. Comb. Chem. (2000), 2(6), 732-735. 23. Byk, Gerardo; Wetzer, Barbara; Frederic, Marc; Dubertret, Catherine; Pitard, Bruno; Jaslin, Gabrielle; Scherman, Daniel. Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene Expression. J. Med. Chem. (2000), 43(23), 4377-4387. 24. Byk, Gerardo; Scherman, Daniel. Genetic chemistry: tools for gene therapy coming from unexpected directions. Drug Dev. Res. (2000), 50(3/4), 566-572. 25. Soto, Javier; Bessodes, Michel; Pitard, Bruno; Mailhe, Philippe; Scherman, Daniel; Byk, Gerardo. Non-electrostatic complexes with DNA: Towards novel synthetic gene delivery systems. Bioorg. Med. Chem. Lett. (2000), 10(9), 911-914. 26. Frederic, Marc; Scherman, Daniel; Byk, Gerardo. Introduction of cyclic guanidines into cationic lipids for non-viral gene delivery . Tetrahedron Lett. (2000), 41(5), 675-679. 27. Neves, Carole; Byk, Gerardo; Escriou, Virginie; Bussone, Florence; Scherman, Daniel; Wils, Pierre. Novel Method for Covalent Fluorescent Labeling of Plasmid DNA That Maintains Structural Integrity of the Plasmid. Bioconjugate Chem. (2000), 11(1), 51-55. 28. Neves, C.; Escriou, V.; Byk, G.; Scherman, D.; Wils, P. Intracellular fate and nuclear targeting of plasmid DNA. Cell Biol. Toxicol. (1999), 15(3), 193-202. 29. Neves, Carole; Byk, Gerardo; Scherman, Daniel; Wils, Pierre. Coupling of a targeting peptide to plasmid DNA by covalent triple helix formation. FEBS Lett. (1999), 453(1,2), 41-45. 30. Schwartz, B.; Ivanov, M-A.; Pitard, B.; Escriou, V.; Rangara, R.; Byk, G.; Wils, P.; Crouzet, J.; Scherman, D. Synthetic DNA-compacting peptides derived from human sequence enhance cationic lipid-mediated gene transfer in vitro and in vivo. Gene Ther. (1999), 6(2), 282-292. 31. Ciolina, Carole; Byk, Gerardo; Blanche, Francis; Thuillier, Vincent; Scherman, Daniel; Wils, Pierre. Coupling of Nuclear Localization Signals to Plasmid DNA and Specific Interaction of the Conjugates with Importin . Bioconjugate Chem. (1999), 10(1), 49-55. 32. Byk, Gerardo; Scherman, Daniel. Novel cationic lipids for gene delivery and gene therapy. Expert Opin. Ther. Pat. (1998), 8(9), 1125-1141. 33. Byk, Gerardo; Soto, Javier; Mattler, Christophe; Frederic, Marc; Scherman, Daniel. Novel non-viral vectors for gene delivery: synthesis of a second-generation library of mono-functionalized poly-(guanidinium)amines and their introduction into cationic lipids. Biotechnol. Bioeng. (1998), 61(2), 81-87. 34. Byk, Gerardo; Dubertret, Catherine; Escriou, Virginie; Frederic, Marc; Jaslin, Gabrielle; Rangara, Ravi; Pitard, Bruno; Crouzet, Joel; Wils, Pierre; Schwartz, Bertrand; Scherman, Daniel. Synthesis, Activity, and Structure-Activity Relationship Studies of Novel Cationic Lipids for DNA Transfer. J. Med. Chem. (1998), 41(2), 224-235. 35. Escriou, Virginie; Ciolina, Carole; Lacroix, Florence; Byk, Gerardo; Scherman, Daniel; Wils, Pierre. Cationic lipid-mediated gene transfer: effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes Biochim. Biophys. Acta (1998), 1368(2), 276-288. 36. Byk, Gerardo; Dubertret, Catherine; Schwartz, Bertrand; Frederic, Marc; Jaslin, Gabrielle; Rangara, Ravi; Scherman, Daniel. Novel nonviral vectors for gene delivery: synthesis and applications. Lett. Pept. Sci. (1997), 4(4/5/6), 263-267. 37. Pitard, Bruno; Aguerre, Olivier; Airiau, marc; Lachages, Anne-Marie; Boukhnikachvili, Tsiala; Byk, Gerardo; Dubertret, Catherine; Herviou, Christian; Scherman, Daniel; Mayaux, Jean-Francois; Crouzet, Joel. Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer. Proc. Natl. Acad. Sci. U. S. A. (1997), 94(26), 14412-14417. 38. Byk, Gerardo; Frederic, Marc; Scherman, Daniel. One pot synthesis of unsymmetrically functionalized polyamines by a solid phase strategy starting from their symmetrical polyamine-counterparts. Tetrahedron Lett. (1997), 38(18), 3219-3222. 39. Byk, Gerardo; Lelievre, Yves; Duchesne, Marc; Clerc, Francois F.; Scherman, Daniel; Guitton, Jean Dominique. Synthesis and conformational analysis of peptide inhibitors of farnesyltransferase. Bioorg. Med. Chem. (1997), 5(1), 115-124. 40. Byk, Gerardo and Scherman Daniel: Synthesis of novel (N-farnesyl)amino acids and their incorporation into peptides. Int. J. Peptide Protein Res. (1996), 47, 333-339. 41. Bitan, Gal; Zeltser, Irena; Byk, Gerardo; Halle, David; Mashriki, Yaffa; Gluhov, Evgenia V.; Sukhotinsky, Inna; Hanani, Menachem; Selinger, Zvi; Gilon, Chaim. Backbone cyclization of the C-terminal part of substance P. Part 1: The important role of the sulfur in position 11. J. Pept. Sci. (1996), 2(4), 261-269. 42. Byk, Gerardo; Halle, David; Zeltser, Irena; Bitan, Gal; Selinger, Zvi; Gilon, Chaim. Synthesis and Biological Activity of NK-1 Selective, N-Backbone Cyclic Analogs of the C-Terminal Hexapeptide of Substance P. J. Med. Chem. (1996), 39(16), 3174-3178. 43. Byk, Gerardo; Duchesne, Marc; Parker, Fabienne; Lelievre, Yves; Guitton, Jean D.; Clerc, Francois F.; Becquart, Jerome; Tocque, Bruno; Scherman, Daniel; et al. Local constrained shifty pseudopeptides inhibitors of ras-farnesyl transferase. Bioorg. Med. Chem. Lett. (1995), 5(22), 2677-82. 44. Grdadolnik, Simona Golic; Mierke, Dale F.; Byk, Gerardo; Zeltser, Irena; Gilon, Chaim; Kessler, Horst. Comparison of the Conformation of Active and Nonactive Backbone Cyclic Analogs of Substance P as a Tool To Elucidate Features of the Bioactive Conformation: NMR and Molecular Dynamics in DMSO and Water. J. Med. Chem. (1994), 37(14), 2145-52. 45. Byk, Gerardo and McGregor, John L. Role of Type I Motif CSVTCG in the Thronbispondin Interaction with other Adhesive Proteins: Effect on Platelet Aggregation. Thrombosis-Haemostasis (1993) 69, 1009. 46. Byk, Gerardo; Gilon, Chaim. Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(-aminoalkylene)amino acids and their incorporation into dipeptide units. J. Org. Chem. (1992), 57(21), 5687-92. 47. Saulitis, Juris; Mierke, Dale F.; Byk, Gerardo; Gilon, Chaim; Kessler, Horst. Conformation of cyclic analogs of substance P: NMR and molecular dynamics in dimethyl sulfoxide. J. Am. Chem. Soc. (1992), 114(12), 4818-27. 48. Gilon, Chaim; Halle, David; Chorev, Michael; Selinger, Zvi; Byk, Gerardo. Backbone cyclization: a new method for conferring conformational constraint on peptides. Biopolymers (1991), 31(6), 745-50. Articles in Proceedings Books of International Scientific Meetings 49. Byk, , Gerardo and Kabha, Eihab, Regioselective MCR4 reaction: One Pot Synthesis of Spiro Hetetrobicyclic Aliphatic Rings generated from Natural Amino Acids: in Peptide Revolution:Genomics,Proteomics &Therapeutics Michael Chorev &Tomi K.Sawyer (Editors) American Peptide Society (2003) pg 104-105. 50. Byk, Gerardo; Haas, Elisha; Ittah, Vardah and Rofman Inbar: A Versatile Method for Fast and Selective Introduction of Multiple Probes into Peptides Using Solid Phase Synthesis-Application to Biophysical Models. In Peptide Revolution: Genomics,Proteomics &Therapeutics Michael Chorev &Tomi K.Sawyer (Editors) American Peptide Society (2003) pg 91-92. 51. Byk, Gerardo; Engel, Dikla; Ittah, Vardah; Haas, Elisha: Peptide models for studying autonomous folding of subdomain sections of protein molecules. In Peptides: The Wave of the Future, Proceedings of the Second International and the Seventeenth American Peptide Symposium, San Diego, CA, United States, June 9-14, 2001 (2001), 398-399 52. Byk, Gerardo; Dubertret, Catherine; Schwartz, Bertrand; Frederic, Marc; Jaslin, Gabrielle; Scherman, Daniel. Synthesis, characterization and use of novel nonviral vectors for gene delivery. Editor(s): Tam, James P.; Kaumaya, Pravin T. P. Pept. Proc. Am. Pept. Symp., 15th (1999), Meeting Date 1997, 823-824. Publisher: Kluwer, Dordrecht, Netherlands. 53. Byk, Gerardo; Frederic, Marc; Scherman, Daniel. Unsymmetrically functionalized polyamine libraries by a solid phase strategy starting from their symmetrical polyamine-counterparts. Editor(s): Tam, James P.; Kaumaya, Pravin T. P. Pept. Proc. Am. Pept. Symp., 15th (1999), Meeting Date 1997, 47-48. Publisher: Kluwer, Dordrecht, Netherlands 54. Bitan, G.; Byk, G.; Mashriki, Y.; Hanani, M.; Halle, D.; Selinger, Z.; Gilon, C. Structure-activity relationship studies of new backbone-cyclic substance P analogs. Editor(s): Kaumaya, Pravin T. P.; Hodges, Robert S. Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 14th (1996), Meeting Date 1995, 697-698. Publisher: Mayflower Scientific, Kingswinford, UK 55. Byk, G.; Burns, C.; Duchesne, M.; Parker, F.; Lelievre, Y.; Guitton, J. D.; Clerc, F. F.; Commercon, A.; Tocque, B.; et al. Constrained pseudopeptides as inhibitors of Ras-farnesyl transferase: Structure-activity relationship studies. Editor(s): Kaumaya, Pravin T. P.; Hodges, Robert S. Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 14th (1996), Meeting Date 1995, 213-214. Publisher: Mayflower Scientific, Kingswinford, UK 56. Byk, G.; Scherman, D. Synthesis of backbone-modified (N-farnesyl) amino acids and their incorporation into peptides. Editor(s): Kaumaya, Pravin T. P.; Hodges, Robert S. Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 14th (1996), Meeting Date 1995, 107-108. Publisher: Mayflower Scientific, Kingswinford, UK 57. Byk, Gerardo; McGregor, John L. Peptide analogs derived from the thrombospondin type I repeat (CSVTCG) inhibit platelet aggregation. Editor(s): Schneider, Conrad H.; Eberle, Alex N. Pept. 1992, Proc. Eur. Pept. Symp., 22nd (1993), Meeting Date 1992, 827-8. Publisher: ESCOM, Leiden, Neth 58. Gilon, Chaim; Zeltser, Irena; Rashti-Bahar, Vered; Muller, Dan; Bitan, Gal; Halle, David; Bar-Akiva, Giora; Selinger, Zvi; Byk, Gerardo. Backbone cyclization as a tool for imposing conformational constraint on peptides. Editor(s): Yanaihara, Noboru. Pept. Chem. 1992, Proc. Jpn. Symp., 2nd (1993), Meeting Date 1992, 482-5. Publisher: ESCOM, Leiden, Neth 59. Gilon, C.; Halle, D.; Chorev, M.; Selinger, Z.; Byk, G.. SAR studies of cycloseptide: Effects of cyclization and charge at position 6. Editor(s): Smith, John A.; Rivier, Jean E. Pept.: Chem. Biol., Proc. Am. Pept. Symp., 12th (1992), Meeting Date 1991, 476-7. Publisher: ESCOM, Leiden, Neth 60. Gilon, Chaim; Halle, David; Chorev, Michael; Selinger, Zvi; Goldshmith, Rafi; Byk, Gerardo. Backbone-to-end cyclic tachykinins: a new approach to conformationally restricted peptides. Editor(s): Giralt, Ernest; Andreu, David. Pept. 1990, Proc. Eur. Pept. Symp., 21st (1991), Meeting Date 1990, 404-6. Publisher: ESCOM Sci. Publ., Leiden, Neth 61. Byk, Gerardo; Gur, Erez; Halle, David; Chorev, Michael; Selinger, Zvi; Gilon, Chaim. A new route to prepare conformationally restricted cyclic peptides as demonstrated by a potent NK-1 selective substance P analog. Editor(s): Rivier, Jean E.; Marshall, Garland R. Pept.: Chem., Struct. Biol., Proc. Am. Pept. Symp., 11th (1990), Meeting Date 1989, 984-5. Publisher: ESCOM Sci. Pub., Leiden, Neth

Researchgroup, Institute, University, School, Company name

Bar Ilan University, Ramat Gan , Israel

Researchgroup, Institute, Company, University, School webpage

https://www.wix.com/gerardobyk/nanobiotechnology

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