Some redox-active metals in carbon nanoparticles and their biological relevance
Blanka Emődy-Kiss, Zsolt Halász, János Fent
Hungarian Defence Forces Medical Centre
H-1134, Róbert Károly krt. 44, Budapest, Hungary
Abstract
Residual metal contaminants from catalyst systems used in nanoparticle synthesis may significantly influence the biological effects of carbon-based nanomaterials. Redox-active metals, in particular, are known to disrupt cellular redox homeostasis and enzyme function.
In this study, metal contents were quantified by ICP-MS analysis in single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), diesel-derived nanoparticles, and carbon black nanoparticles. Based on their elemental profiles, the samples were classified into three groups: Mo–Co-contaminated, Ni-contaminated, and metal-poor nanomaterials. These levels were evaluated against physiological values in healthy individuals, providing a biologically relevant framework for estimating potential toxicological effects.
These results highlight the need for the characterization of metal contaminants in nanotoxicological studies.
In this study, metal contents were quantified by ICP-MS analysis in single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), diesel-derived nanoparticles, and carbon black nanoparticles. Based on their elemental profiles, the samples were classified into three groups: Mo–Co-contaminated, Ni-contaminated, and metal-poor nanomaterials. These levels were evaluated against physiological values in healthy individuals, providing a biologically relevant framework for estimating potential toxicological effects.
These results highlight the need for the characterization of metal contaminants in nanotoxicological studies.
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