Gold Nanoparticles Synthesis Using Syzygium cumini Leaf Extract and Examination of Its antioxidant, tyrosinase inhibition, and antibacterial properties

Gitishree Das, and Jayanta Kumar Patra*

Research Institute of Integrative Life Sciences, Dongguk University-Seoul, Goyangsi, Republic of Korea.

Abstract:

In this study, gold nanoparticles were synthesized by a one-pot synthesis method using Syzygium cumini leaf aqueous extract as a reducing, capping, and stabilizing agent. After synthesis, the gold nanoparticles were tested for their antioxidant, tyrosinase inhibition, and antibacterial properties using standardized experimental designs. The UV-Vis spectral surface plasmon resonance at 530 nm confirmed the successful synthesis of the nanoparticle. The average particle size was determined as 122.2 nm with Pdi = 0.152, and – 25.9 mV zeta potential. The synthesized nanoparticle displayed enhanced antioxidant effects with around 90% of DPPH activity and 70% of ABTS activity. It exhibited about 30% of tyrosinase inhibition at 100 µg/ml concentration. The nanoparticles showed strong inhibition against the tested pathogenic bacteria. In conclusion, the results of the current investigation advocated the encouraging application of synthesized nanoparticles in the food and cosmetics industries.

Keywords: Gold nanoparticles; antioxidant; antibacterial; tyrosinase inhibition