Improving the Solubility of curcumin by various nanoparticles by chemical method

Vinayak A. Dhumale1*, Rajesh k. Gangwar2

1 - Department of Engineering Science & Humanities, School of Engineering and Science, MIT Art Design and Technology University, Pune, India
2 - Council of Science & Technology U.P. (DST, Govt. of U.P.), Lucknow, India

Abstract:
Curcumin is known for its superior biological and pharmacological properties such as antiseptic, antioxidant, chemo-preventive, anti-inflammatory, anti-diabetic, antiviral, anti- carcinogenic and antibacterial etc. It is obtained from roots of turmeric plant. Turmeric contains variety of ingredients but most important curcumin. The curcumin is insoluble in water medium due to which its applications are limited. Poor bioavailability of curcumin in body leads to its poor activity, low absorption and rapid elimination from the system. This is a major obstacle in making a drug for clinical trials. So researchers are trying to increase the solubility of curcumin in aqueous medium.
In the current work different nanopartciles i.e. gold, silver, silica etc have been used for improving the solubility of curcumin. A simple wet chemical method has been utilized for the synthesis curcumin conjugation with various nanoparticles. The synthesized curcumin conjugated nanoparticles have been analyzed by various characterization tools such as UV-Vis spectroscopy, FTIR, SEM/TEM etc.
The synthesized conjugate can be utilized for testing antibacterial, antimicrobial, anticancer application.