Multifunctionalized Surfaces to Improve Implant Performance

*F. Ghilini(1), M. C. Rodríguez González(2), A. G. Miñán(1), D. E. Pissinis(1), N. S. Fagali(1), A. Hernández Creus(2), R. C. Salvarezza(1) y
P. L. Schilardi(1)

1 - Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Facultad de Ciencias Exactas, UNLP - CONICET- Diagonal 113 esq 64 s/n, (1900) La Plata, Buenos Aires, Argentina.
2 - Instituto Universitario de Materiales y Nanotecnología (IMN), Universidad de La Laguna, Avda. Francisco Sánchez, s/n, La Laguna, Tenerife, España.

Abstract: Implant infection  incidence is rising up nowadays, stimulating  researches to trigger new materials able to inhibit bacterial growth. In this regard, several strategies on surfaces, modification have been studied such as  antibiotic adsorption, polymer coatings, or photoactive molecules [1]. Although,  most of them present bacteriostatic action and poor analysis of cytotoxic impact on eukaryotic cells [2]. The aim of this work is to design simple titanium functionalization strategies using biomolecules to obtain biomaterials with antimicrobial properties that ensure the success of the implant, reducing healing time and thus improving the patient’s life quality. Two systems were developed, one using poly-L-lysine (PLL) as an attractor for silver nanoparticles (AgNPs) of different sizes, and the other combining lactoferrin (Lf) with AgNPs. The surfaces were characterized by XPS, FTIR, contact angle and AFM and the biologic interaction were studied by antimicrobial assays and osteoblast adhesion assays. The materials exhibited great biocompatibility and antibacterial properties. Thus, this development could be used as a novel biomaterial to ensure implant success.



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