Improving Aqueous Solubility of Curcumin by Silver Nanoparticles and its Antibacterial Activity

Authors: Rajesh K. Gangwar, Bindu Arora, Alka Sawaikar, Suwarna S. Datar and Vinayak A. Dhumale*

1 Department of Applied Physics, DIAT (DU), Pune-411 025,
2 Department of Biotechnology, Abasaheb Garware College, Pune- 411 004,
3 Department of General Science, MMCOE, Pune-411 052,
4 Department of Engineering Sciences & Humanity MIT ADT University, Pune-412 201,
5 Council of Science & Technology, (DST, Govt. of U.P.) Lucknow- 226 018

Abstract: A yellow compound Curcumin, known for its superior biological and pharmacological properties obtained from the roots of plant Turmeric. The curcumin is insoluble in aqueous media therefore it’s applications are limited. So this research work aims to increase its solubility in water medium.
In this silver nanoparticles were synthesized by wet chemical method and capped with curcumin. The Polyvinyl Pyrrolidone (PVP) is used as a binder between silver nanoparticles and curcumin. The synthesized conjugate is characterized by UV Vis spectroscopy, FTIR, and FESEM. The size of conjugate is found in the range of 40-65 nm as confirmed by FESEM. Further the conjugation of curcumin with silver nanoparticles showed good antibacterial activity against P. aeroginosa, E. coli and B. cereus.


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