ANTIVIRAL NANOMATERIALS AS COATINGS TO COMBAT VIRAL INFECTIONS
Soumyadeep Basak(a), Gopinath Packirisamy(a, b)
(a) Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee -247667, Uttarakhand, India
(b) Nanobiotechnology Laboratory, Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee -247667, Uttarakhand, India
In human history, unprecedented challenges have been brought about by viral emergencies in the form of pandemics or epidemics, leading to severe financial and social difficulties. In the form of COVID-19, with an ever-increasing death toll, the most recent one, the SARS-CoV-2, has already taken approximately 2.8 million lives globally (2,769,696 as of 28th March 2021). The nosocomial route and several viral transmission modes have also played a major role in the community transmission of certain viruses. Unfortunately, the past year had been a significant delineator to the fact that none of the existing antimicrobial strategies are apt for combatting the sudden emergence or re-emergence of microbial diseases. The principal target to contain a viral infection is to control its spread, i.e., stopping the virus from infecting otherwise healthy individuals. In such a scenario, nanotechnology has provided us with several functional nanomaterials and nanomaterial coatings to prevent viral transmission. It has also provided us with affordable and easy to maintain strategies to prevent the virus from infecting susceptible individuals. Moreover, the fascinating nature of antimicrobial nanomaterials is their non-specificity and broad-spectrum activity, which is their ability to inactivate a large variety of microbes through a single platform. Apart from that, the interference to viral attachment provided by the multivalent nature of nanomaterials makes them suitable candidates to interfere with the viral entry to the host cell. In this work, several nanotechnology-based potential antimicrobial strategies, in the form of nano-coatings, have been discussed that would provide us with excellent platforms to prevent viral transmission.
Keywords: Antimicrobial, Antiviral, Coating, Nanomaterials
The authors acknowledge the Centre for Nanotechnology, Indian Institute of Technology Roorkee and Department of Biotechnology, Government of India (BT/PR 25095/NER/95/1011/2017)
S. Basak, G. Packirisamy, Nano-based antiviral coatings to combat viral infections, Nano-Structures and Nano-Objects. 24 (2020) 100620. https://doi.org/10.1016/j.nanoso.2020.100620.