Green Biosynthesis of Sericin based nanoparticles and their potential applications in biomedical and pharmacological fields
Jayanta Kumar Patra*, Gitishree Das
Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, Republic of Korea
Nano-based formulations have been proposed as a major tool that could modernize the current drug delivery systems. Protein-based nanocarriers have been widely studied for nano formulation production, due to their inherent properties, such as biodegradability, biocompatibility, self-organization, and low toxicity. Besides, proteins are easily functionalized due to the large quantity of hydroxyl, amino, and carboxyl groups, which are subjected to chemical modification. Amongst the proteins, silk proteins such as sericin, have been used to develop nano-based formulations owing to its numerous physicochemical and biomedical properties. Sericin has been described as a protein with extensive uses in the medical field with a promising future in tissue engineering, diagnosis, and disease therapies. This protein biopolymer has been used as inert or non-inert support to fabricate films, sponges, fibers, patches, scaffolds, hydrogels, micro, and nanostructures. Among these materials, nanostructures have been highlighted considering their antibacterial effects, wound healing, artificial skin, articular cartilage, scaffolds for tissue regeneration, and small molecules delivery systems. The current study highlights the potential applications of sericin based nanomaterials in the field of biomedical and pharmaceutical field.
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1G1A1004667), the Republic of Korea.