Dear Nanotechnology Researchers,


    Can anyone tell me that what are all the toxicological studies i can do with different nanoparticles.If anybody can answer for this it will be very usefull for my research. 

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  • How long will take to finish one systematic toxicological study of particular nanoparticle?
    • it depends on what study you are itrested in? there are diff toxicology studies including cronic toxicity,acute toxicity,and many more....
  • sory for late reply... whatever Mr. Amod has mentioned is right and all the tests that i hav mentioned check for one of those possibible effects of nanoparticles on mammalian cells. the procedure for these tests is very simple and easily available on internet.
  • Hello,
    I am also a Microbiologist, and very much new in to nanotech... i think when we talk about nanostructures the primary mechanism of its toxicity is in its small (nano) form, i.e. particles with new physics e.g: increased surface area to vol ratio, eventually making that particular nanoparticle with high chemical and biological activity... the greater chemical reactivity reselts in increased production of Reactive Oxygen Species (ROS), including free radicals...evident in case of C-60, CNTs, and metal oxides.. ultimate result is oxidative stress, inflamation and damage to proteins membs, and DNA. the extremely small size of nanomaterials also means that they are much more readily taken up by the body, able to cross biological membs, and access cells, tissues and organs that larger sized particles normally cannot...nanoparticles can gain access to the blood stream following inhalation or ingestion.. broken skin is an ineffective particle barrier, enable skin uptake of nanomaterials more readily.. once in blood stream, they can transported around the body and taken up by organs and tissues such as heart, liver, kidneys, spleen, nervous system... (Nano) Size is therefore a key factor in determining the potential toxicity of a particle... however it is not the sole discussed by Mr. Debasis...
    sry for very late reply...

    • thank u sir....

      whether particle shape interfere with toxicity?
  • check our nanotoxicology group also:
  • sir... i am very new in nanotechnology but being a biotechnologist,i can say that cytotoxicity studied, like LDH assay, MTT assay, DNA fragmentation assay,etc that are carried out on human cell lines,may be usefull. also some bacteriological assays like AMES test for mutagenecity are also usefull.
    • Thank you very much mam.....
      I am also very new to the nanotechnology. Am a microbiologisat. What u r disscussing exactly covering the topics wat am thinking.Can u tell me something about this mutagenesis.
      • you can do mutagenesis study from Intox pvt ltd comny were i was waorked for 1 year...go to website..
  • There's very few studies done in toxicological effects of nanomaterials in marine environments. I'm doing a research project on marine red algae (Ag). It depends on what particles your interested in and which angle you are coming from (environmental, human health, ecological-like bioaccumulation). Tell me what you are interested in and send me an e-mail at
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