The project involves development and application of atomic force microscopy (AFM) methods to study the process of drug binding to cell surface receptors by time-lapse atomic force microscopy. Development of sample preparation and imaging protocols. Time-lapse AFM imaging of conformational changes in cell surface receptors on drug binding, using both commercial and home-built AFM equipment.
The work will be carried out in the London Centre for Nanotechnology at UCL and in close collaboration with scientists at the MedImmune laboratories in Cambridge.
The appointment is funded by MedImmune, the biologics research arm of AstraZeneca and is for a duration of six months.Applicants should have a PhD (or by the start date at least have submitted their thesis) in physics, engineering or life sciences. It is essential that they have experience of submolecular-resolution atomic force microscopy in aqueous environment. Experience of operating home-built scanning probe microscopy equipment is also required.
A job description and person specification can be accessed at the bottom of this page.
Further details about the post and the application procedure are also available at http://www.london-nano.com/our-people/vacancies/all.
For informal enquiries please contact Dr. Bart Hoogenboom b.hoogenboom@ucl.ac.uk.
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