Postdoc position on DNA grafting on nanostructure for X-ray holographic recording

The concept of holography has been proposed in the 40s by Dennis Gabor for electron microscopy. Then the invention of the laser made possible its application for authentication or for optical metrology. The molecular identification by imaging techniques applied to macromolecules (polymer or deoxyribonucleic acid DNA) is a complementary alternative methods for analysis and sequencing [1]. LETI has already studied surface functionalization techniques and DNA grafting [2] and have developed an extreme Ultraviolet interferometer, (l = 13.5nm, 92eV) for ultimate lithography studies [3]. In the frame of the expertise of our institute in surface chemistry, biochemistry, nanotechnology and X-ray characterization, this topic offers to develop methods and processes for DNA grafting on nanostructures to produce samples dedicated to synchrotron experiments for recording holographic pictures.

The candidate will develop methods and processes for DNA confinement and grafting on nanostructures such as nanodots or nanochannels in silicon or other materials. From these methods and processes he will produce samples as model or reference to check the X-ray measurement on synchrotron by Small Angle X-ray Scattering technique. Then a new set of samples will be fabricated with grafted DNA into an X-ray interferometer to produce hologram recording. The candidate will participate to the synchrotron experiments for the sample characterizations.

The results will be disseminated in form both of journal publications and of patents and at international conferences.

[1] Jonathan Jeffet, Asaf Kobo, Tianxiang Su, Assaf Grunwald, Ori Green, Adam N. Nilsson, Eli Eisenberg, Tobias Ambjörnsson, Fredrik Westerlund Elmar Weinhold, Doron Shabat, Prashant K. Purohit and Yuval Ebenstein, Super-Resolution Genome Mapping in Silicon Nanochannels, 2016 ACS nano, DOI: 10.1021/acsnano.6b05398.

[2] Rull, J.; Nonglaton, G.; Costa, G.; Fontelaye, C.; Marchi-Delapierre, C.; Ménage, S.; Marchand, G., Functionalization of silicon oxide using supercritical fluid deposition of 3,4-epoxybutyltrimethoxysilane for the immobilization of aminomodified

oligonucleotide. Appl. Surf. Sci. Vol. 354, 2015, Part B, Pages 285-297.

[3] Constancias, C., Dalzotto, B., Michallon, P, Wallace, J., Saib, M., Fabrication of large area ultrathin silicon membrane:

Application for high efficiency extreme ultraviolet diffraction gratings, JVST B, Vol. 28, Issue 1, 2010, Pages 194-197

SKILLS AND EXPERIENCE

The subject requires knowledge in bio-chemistry for DNA handling. A good scientific knowledge in physics and technology will facilitate exchanges with the project partners. This study is conducted in collaboration with several laboratories of LETI. Also we call for a candidate with good communication skills and autonomy to lead and organize the interaction with the teams involved in this project.

If you are interested, please send your CV, including contact information of two references, and a short statement describing experience, goals and reasons for the interest in this position to:

Start date: September 1st 2017

Contact: christophe.constancias@cea.fr

ABOUT THE EMPLOYER

Leti is a technological research institute of CEA Tech and a recognized global leader specializing in nanotechnology and materials for micro and nanosystems and their applications from space to smart devices. Based in Grenoble, France, Leti has ongoing scientific collaborations with Stanford University, MIT, EPFL, FZ Jülich and other major research organizations and academic institutions.

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