Post-doc position available in Canada

Dear Colleagues, I am looking for a post-doctorate fellow to work on the project entitled "Medical diagnostic tool for platelet activation evaluation from whole blood samples". In hemostasis, platelets rapidly adhere at sites of vessel wall injuries, aggregate and form a hemostatic plug that is strengthened by a fibrin network. At the onset of this phenomenon, platelets adhere on von Willebrand factor, collagen and fibronectin located in exposed extracellular matrix after vessel injury. The exposition of platelets to these molecules induces important changes in their morphology and physiology, which are needed to stimulate platelet aggregation and fibrin formation. This process is termed platelet activation. In contrast to non-activated platelets, activated ones, for example, express the trans-membrane protein P-selectin, present an alternate conformation of the GPIIb/IIIa integrin and even extend pseudopods to enhance aggregation. The clinical significance of platelet activation is very important. An increased platelet activation level in circulating blood has been demonstrated to be an important stroke and ACS risk factor and is thought to precede these acute events The overall aim of this project is to develop and to validate a medical diagnostic kit to rapidly detect platelet activation level from whole blood. The specific objectives are: 1. To rapidly detect platelet activation levels with a large level of confidence in patients at-risk, or being treated for platelet activation disorders such as cardiovascular diseases. 2. To detect platelet activation in blood products. 3. To miniaturize the instrument to be used during blood tests. 4. To develop an automated detection and interpretation module that may “read” the diagnostic surfaces and yield an easy to interpret result. This project involves: 1. The development and surface characterization of bioactive surfaces to capture activated platelets from whole blood. 2. The validation in clinic of novel medical diagnostic tools based on previous research and development efforts. 3. To make the link between physicians and researchers. The candidate would join a very dynamic and interdisciplinary Team. Candidates must have a background in biochemistry, biology, biomaterials, physic engineering, or chemical engineering. Candidates must be curious, creative, rigorous, and highly motivated. Candidates will gain knowledge in surface chemistry and physics, colloidal science, biomaterials, material science, and cell biology. KeyWords: Biomaterials; Surface chemistry; Biosensors. For more information, please do not hesitate to contact: Patrick Vermette, Professor, P. Eng. Département de génie chimique et de génie biotechnologique Université de Sherbrooke 2500, boulevard de l'Université Sherbrooke, Québec Canada, J1K 2R1 E-mail: Patrick.Vermette@USherbrooke.ca Telephone: 1-819-821-8000 ext. 62826 Fax: 1-819-821-7955 http://www.chimique.usherbrooke.ca/biogenie/

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Comments

K.Varaprasad May 9, 2010 at 6:00pm

This varaprasad.K I am searching for PDF in nano feild, can i apply this
nnamdi OKeke January 26, 2010 at 10:28pm

I am searching for a position in nanobiothnology and nanomedicine related with my master in engineering physic please let me know if this still available
thank
M.Saravanan January 3, 2010 at 3:57pm

Dear sir
I am searching for PDF position in Nanobiotechnology and Nanomedicine related research, I can send My resume for kind consideration

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