Postdoc in "Analysis of Noncovalent Protein Complexes" / "Instrument Development"

Research context:
The group of Prof. Frank Sobott at the University of Antwerp (Belgium) develops and uses methods based on nano-ESI, native mass spectrometry and ion mobility, to investigate large noncovalent assemblies of (bio-)molecules. Current topics include protein and DNA/RNA conformational studies and the assembly, architecture and dynamics of complexes. We are also developing and modifying instrumentation, in collaboration with manufacturers. The lab has a Synapt G2 (with ETD and SID option) and a high-mass Q-Tof2 and will acquire a customized Synapt G1 for the purpose of this project.

Description

The candidate will be employed in the group of Frank Sobott, to lead efforts in the development and application of new experimental methods for “native” MS and ion mobility, including top-down sequencing and native conformational mapping with both ETD and SID, surface labelling and computational approaches. A major focus of the project will be to develop devices and methods for soft-landing of macromolecular complexes inside the mass spectrometer (“preparative mass spectrometry”), for further structural analysis e.g. by electron microscopy, in collaboration with instrument manufacturers.

Nr of positions available : 1

Research Fields

Chemistry

Career Stage

Experienced researcher or 4-10 yrs (Post-Doc)

Research Profile

Established Researcher (R3)

Benefits

• An exciting opportunity for personal development at the cutting edge of current mass spectrometry research
• A unique opportunity to collaborate with leading structural biologists and protein biochemists across Europe
• State-of-the-art equipment, including a Waters Synapt G2 with SID and ETD
• A contract for 2 years initially, with a view to extension for another 2 years
Starting date will be July 2014 or later, depending on the candidate.

Comment/web site for additional job details

Please e-mail your:
• Detailed CV
• List of publications
• One page description on previous research experience, skills and research interests
• Names and addresses of 2 referees

Informal enquiries and applications (including cover letter, CV and references) should be sent to: frank.sobott@uantwerpen.be.

Requirements
Required Languages
Language
ENGLISH
Language Level
Excellent
Additional Requirements • Senior or junior postdoctoral researcher with a background in (physical) chemistry, physics, engineering, or biochemistry
• A strong background in instrumentation and method development, e.g. biophysics or analytical chemistry, ideally including mass spectrometry
• Prior knowledge in structural biology or biochemistry is not essential, but a bonus. A strong interest in these fields is required.
• Excellent writing, reporting and communicative skills in English
• Willingness to travel occasionally for collaborative meetings and conferences
• Willingness to supervise Ph.D. and master students