EC Marie Curie ITN Network 3 year PhD studentship in: Single molecule imaging of the DNA Damage Response

We are seeking to appoint a PhD student in the field of single molecule microscopy applied to imaging the DNA damage response (DDR). Understanding the mechanism by which the cell maintains genome stability under stress is
not only key to providing new insights into cell mutation and carcinogenesis, but also the development of tailored therapies and medical interventions at the molecular level.

The University of Sussex UK led project aims to image DDR at the level of single DNA and chromatin fibres in order to directly visualise the proteins associated with sites of damage and stalled replication forks. As part of an
EU wide initial training network (ITN), the project provides an opportunity for the successful candidate to engage in highly multidisciplinary research using state-of-the-art laser microscopy, molecular immobilisation and
fluorescent protein tagging techniques. The training will involve the development of ultra-sensitive detection for single molecule imaging and DNA display techniques for fluorescence and scanning probe microscopy.

EU candidates (not UK) with a background in physics or physical chemistry or biophysics and a strong interest in the application of laser spectroscopy, optics and microscopy in the biosciences can seek further details from Dr.
Mark Osborne (m.osborne@sussex.ac.uk) or Prof. Tony Carr (a.m.carr@sussex.ac.uk). (Please include a CV with your enquiry).

Application enquiries to Karen White (email: pglifesci@sussex.ac.uk) or online at
http://www.sussex.ac.uk/Units/publications/pgrad2009/applynow