Project title: Preventing nano- and micro- wear particles induced inflammation The aim of the project is to prepare orthopaedic implants eluting anti-inflammatory drugs through various mechanisms such as: mixing, infusion and surface coating of different parts of the device. Both steroidal and non-steroidal drugs will be evaluated.
Description
The following parameters and effects on the biological activity of wear particles will be considered: Type of drug Drug eluting mechanism Part of the device drug-impregnated Kinetics of drug release Size and chemical composition of wear debris All testing will be carried out with nano- and micro-size particles generated both in-vitro and in vivo. The study will investigate the responses to the following cells to wear particles: osteoclasts, osteoblasts, bone marrow stromal cells and macrophages. This is an interdisciplinary project and the student will gain knowledge and experience in a wide range of techniques, such as: wet chemistry, surface and material characterisation, molecular and cell biology methods.
15/05/2014
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