Polymers are widely used as biomaterials due to their easy design and preparation, variety of structures and interesting biomimetic properties. Especially in the field of drug delivery, polymeric systems have played an important role since they can deliver therapeutic agents directly to the intended site of action, with improved efficacy. Polymer-drug systems can provide controlled release of both hydrophilic and hydrophobic drugs over long time periods while minimizing unwanted side effects in the body. The project will involve the synthesis of various novel biocompatible polymers with well-defined nanostructures using several modern polymerisation techniques, including reversible addition-fragmentation chain transfer (RAFT) polymerisation and ring opening polymerisation (ROP). The student will receive training in polymer self-assembly methods as well as polymer characterization techniques such as nuclear magnetic resonance (NMR) spectroscopy, gel permeation chromatography (GPC), dynamic light scattering (DLS), transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The synthesised polymeric nanomaterials will be examined for their biocompatibility and will be used for intracellular drug delivery.

Applications are requested from UK students who have at least a 2:1 Hons degree (or equivalent) in Chemical Engineering, Chemistry, Materials Science, Biomedical Science or a closely related subject and a strong interest and motivation in pursuing research in polymeric biomaterials. A full stipend is available for 3 years (£13,726 per annum) together with the associated fees. The project will be undertaken under the supervision of Dr Efrosyni Themistou and will involve the potential for the successful candidate to work in collaborator laboratories during their research project.

For further information, please contact e.themistou@qub.ac.uk.