Laser waves focused on the tumor area can damage cancer cells and blood vessels feeding them. The process becomes more efficient if nanoparticles are preliminary introduced into the tumor. At the conference “Nanotechnologies in Oncology in 2010”, Russian oncologists explained how laser irradiation is absorbed by nanoparticles, what particular nanoparticles should be used and to what extent their application increases therapeutic effect with animals suffering with cancer.

Pulsed laser hyperthermia is the tumor elimination method based on injecting sensitizers (nanoparticles) into the pathological tissue and further irradiation by high-energy laser pulses, the wave length of which is the area of applied nanoparticles absorption. Efficiency and mechanism of action of this approach were studied by specialists of the  Moscow Scientific Research Institute of Oncology named after P.A. Hertzen, State Research Center “NIOPIK” and the A.N. Frumkin Institute of Physical Chemistry and Electrochemistry. Andrei Pankratov and his colleagues investigated more than 15 nanostructure varieties of different chemical nature, structure and size. Nanoparticles of zinc phthalocyanine (ZnPc) were researched in most detail. The researchers have demonstrated that pulsed laser hyperthermia involving ZnPc particles use results in lengthy inhibition in growth of tumors of various nature: sarcomata, colon carcinoma, carcinoma of lung, melanoma. Part of the animals (from 10 to 70%, depending on cancer разновидности рака and investigated treatment method) has demonstrated complete recovery.

The mechanism of antitumoral action of pulsed laser hyperthermia with nanoparticles used as sensitizers has not been fully studied yet. The new research enables to state that the main reason of therapeutic effect is destruction of the tumor vascular system. When the tumor is laser-irradiated, nanoparticle microexplosions occur in blood vessels feeding it. The researchers have demonstrated that significant decrease of oxygen partial pressure is observed in the tumor tissues after irradiation: from 40-60 down to 0.5-5 mm of mercury. After irradiation is over, oxygen partial pressure level was not restored with the majority of animals that had underwent treatment with ZnPc particles. Blood vessel destruction in the tumor was also observed when investigation tissues under a microscope. A day after irradiation, blood vessel density in the tumor was almost 10 times lower than that in the reference group (unfortunately, several days after irradiation, vessel growth restarts in the tumor).

The researchers have also investigated safety of nanoparticles they used. They have demonstrated that ZnPc nanoparticles are removed from the blood flow within 3 hours, that the maximum endurable dose in case of intravenous induction exceeds the minimal dose necessary for treatment by 35 times, and that nanoparticles at the 0.2% concentration do not lead to blood corpuscle destruction. Nanoparticles are able to accumulate in the lungs, liver, kidneys and spleen, however, a year after nanoparticle injections, including those in high doses, the researchers did not reveal abnormal changes in these organs.

Source of information: Pankratov A.A., Andreeva T.N.., Yakubovskaya R.I., Kogan B.Ya., Butenin A.V., Feizulova R.A., Rudoi V.M. “Nanostructure composites for laser hyperthermia: various aspects of safety”. Report theses for the “Nanotechnologies in Oncology in 2010” conference.

Further information: Andrei Alexandrovich Pankratov, senior staff scientis, department of modifiers and protectors for antitumoral therapy, Moscow Scientific Research Institute of Oncology named after P.A. Hertzen. Tel. + 7(494)945-87-16, e-mail

Views: 262

Tags: laser, nano, nanoparticle, nanotechnologies, nanotechnology


You need to be a member of The International NanoScience Community to add comments!

Join The International NanoScience Community

Welcome - about us

Welcome! Nanopaprika was cooked up by Hungarian chemistry PhD student in 2007. The main idea was to create something more personal than the other nano networks already on the Internet. Community is open to everyone from post-doctorial researchers and professors to students everywhere.

There is only one important assumption: you have to be interested in nano!

Nanopaprika is always looking for new partners, if you have any idea, contact me at

Dr. András Paszternák, founder of Nanopaprika

Publications by A. Paszternák:

Smartphone-Based Extension of the Curcumin/Cellophane pH Sensing Method

Pd/Ni Synergestic Activity for Hydrogen Oxidation Reaction in Alkaline Conditions

The potential use of cellophane test strips for the quick determination of food colours

pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

Polymeric Honeycombs Decorated by Nickel Nanoparticles

Directed Deposition of Nickel Nanoparticles Using Self-Assembled Organic Template,

Organometallic deposition of ultrasmooth nanoscale Ni film,

Zigzag-shaped nickel nanowires via organometallic template-free route

Surface analytical characterization of passive iron surface modified by alkyl-phosphonic acid layers

Atomic Force Microscopy Studies of Alkyl-Phosphonate SAMs on Mica

Amorphous iron formation due to low energy heavy ion implantation in evaporated 57Fe thin films

Surface modification of passive iron by alkylphosphonic acid layers

Formation and structure of alkylphosphonic acid layers on passive iron

Structure of the nonionic surfactant triethoxy monooctylether C8E3 adsorbed at the free water surface, as seen from surface tension measurements and Monte Carlo simulations

Next partner events of TINC

We are Media Partner of: