Bottom-up Crystallization and Nanoencapsulation Using Microfluidics Reaction Technology

April 23, 2009
Thomai "Mimi" Panagiotou, Ph.D.
Chief Technology Officer

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Microfluidics is pleased to introduce innovative technology for bottom-up creation of nanoparticles via crystallization or chemical reactions. Microfluidics Reaction Technology (MRT) combines the well-established principles of Microfluidizer® high shear fluid processors with expert process development to achieve results not possible with even the most effective particle reduction techniques.

Using MRT, leading pharmaceutical, biotechnology, chemical and energy companies have demonstrated...

* Bottom-up nanoparticle production
* Crystallization of new API's
* Nanoencapsulation
* Micro-reaction
* Process intensification

How It Works
MRT uses a specialized continuous processor with impinging jets in tandem with processes developed by expert nanotechnology application engineers.

In only one pass, MRT has achieved particles sizes 40% smaller than results achieved by 25 passes with leading top-down processors, generating sizes as small as 50 nm.

Azithromycin results

The above results are azithromycin particles produced by solvent/antisolvent crystallization. The z-average particle size was 82 nm and as you can see the product exhibited an extremely narrow distribution.

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pH and CO2 Sensing by Curcumin-Coloured Cellophane Test Strip

Polymeric Honeycombs Decorated by Nickel Nanoparticles

Directed Deposition of Nickel Nanoparticles Using Self-Assembled Organic Template,

Organometallic deposition of ultrasmooth nanoscale Ni film,

Zigzag-shaped nickel nanowires via organometallic template-free route

Surface analytical characterization of passive iron surface modified by alkyl-phosphonic acid layers

Atomic Force Microscopy Studies of Alkyl-Phosphonate SAMs on Mica

Amorphous iron formation due to low energy heavy ion implantation in evaporated 57Fe thin films

Surface modification of passive iron by alkylphosphonic acid layers

Formation and structure of alkylphosphonic acid layers on passive iron

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