Bottom-up Crystallization and Nanoencapsulation Using Microfluidics Reaction Technology

April 23, 2009
Thomai "Mimi" Panagiotou, Ph.D.
Chief Technology Officer

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Microfluidics is pleased to introduce innovative technology for bottom-up creation of nanoparticles via crystallization or chemical reactions. Microfluidics Reaction Technology (MRT) combines the well-established principles of Microfluidizer® high shear fluid processors with expert process development to achieve results not possible with even the most effective particle reduction techniques.

Using MRT, leading pharmaceutical, biotechnology, chemical and energy companies have demonstrated...

* Bottom-up nanoparticle production
* Crystallization of new API's
* Nanoencapsulation
* Micro-reaction
* Process intensification

How It Works
MRT uses a specialized continuous processor with impinging jets in tandem with processes developed by expert nanotechnology application engineers.

In only one pass, MRT has achieved particles sizes 40% smaller than results achieved by 25 passes with leading top-down processors, generating sizes as small as 50 nm.

Azithromycin results

The above results are azithromycin particles produced by solvent/antisolvent crystallization. The z-average particle size was 82 nm and as you can see the product exhibited an extremely narrow distribution.

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