Animation of nanoparticles for drug delivery in cancer treatment

Nanobotmodels Company offer vision of cancer treatment using medical nanoparticles. This short animation shows how drug delivery methods working inside a human body.

Cancer can attack anyone. Since the occurrence of cancer increases as individuals age, most of the cases are seen in adults, middle-aged or older. Sixty percent of all cancers are diagnosed in people who are older than 65 years of age. The most common cancers are skin cancer, lung cancer, colon cancer, breast cancer (in women), and prostate cancer (in men). In addition, cancer of the kidneys, ovaries, uterus, pancreas, bladder, rectum, and blood and lymph node cancer are also included among the 12 major cancers that affect most Americans.

Nanobotmodels Company analyze all scientific progress and clinical tests to make models of nanomedical devices and drug delivery systems. In this animation DNA-origami shell nanoparticle can deliver doxorubicine molecules using specific oncomarkers.

A nanoparticle coated by immune factor, it can prevent attacking nanoparticles by the immune cells. When the nanoparticle conjugate with several specific oncomarkers, it DNA-origami shell opens and doxorubicine flow in the cell’s inner space.

Doxorubicin is one of the chemotherapeutic agents and is commonly used to treat some leukemias and Hodgkin's lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others.

Incide the cell doxorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the progression of the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription. Doxorubicin stabilizes the topoisomerase II complex after it has broken the DNA chain for replication, preventing the DNA double helix from being resealed and thereby stopping the process of replication.

In this type of chemotherapy healthy cells stays undamaged. After successfully drug delivery cancer cell dies.

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