Gene therapy through gene silencing has found a profound potential for curing many diseases and disorders. Virus mediated gene manipulation is one of the prime method of gene silencing and the existing problems related to viral gene silencing in human clinical trials forced many researchers to incorporate various non viral carriers such as nanoparticles. Nowadays, nanoparticles became promising tools for gene silencing for many kind of diseases and genetic abnormalities.
I am looking for an in vivo gene silencing using various nanocarriers for the diseases of brain.
I will be delighted if you could share your ideas and materials for a successful therapeutic option for brain related disorders.