Replies to This Discussion

Permalink Reply by Dr. Murugesan Subbiah on September 25, 2009 at 2:53am

murugesan5@yahoo.com

Permalink Reply by Amod Shepal on September 25, 2009 at 7:13pm

Hello,
In case of Viruss e.g. HIV-I, its a site specific (gp 120 protein recepters) and size dependent binding mechanism that inhibits binding of virus to the host cell.

Amod Shepal
Microbiologist,
Pune, India

Permalink Reply by Amod Shepal on September 25, 2009 at 7:18pm

Hello,
In case of Viruss e.g. HIV-I, its a site specific (gp 120 protein recepters) and size dependent binding mechanism that inhibits binding of virus to the host cell.

Amod Shepal
Microbiologist,
Pune, India.

Permalink Reply by Sumit Arora on September 26, 2009 at 8:24am

1.Strong interaction with thiol groups present in cell respiratory enzymes in the microbe cell.
2.Interaction with structural proteins and preferential binding with DNA bases to inhibit replication.
3.Binding of the silver ion to free sulphydryl groups in the bacterium or on its surface leading to inactivation of the enzyme phosphomannose Isomerase (essential for biosynthesis of cell wall).
Therefore, it attacks many sites simultaneously and microbes can not get resistant easily against silver.

Permalink Reply by sudania2000 on September 27, 2009 at 11:00am

Dear All,
In our culture we have local traditions of wearing silver rings or chains when there is some injures or fever, I would like to ask about wearing the silver rings will affect the bact. or it has to be nano...Regards

Permalink Reply by Idah on September 28, 2009 at 6:09am

dear friends,
Who knows about the technical ionization of nanoparticles silver? How they will be ionized when they are put to water without using the electrodes?

Permalink Reply by CH.L.R.Jaidev on October 5, 2009 at 11:27am

Dear Amod,
Thanx for your reply. How can a nanoparticles becomes toxic When if the same is in bulk?

Permalink Reply by Amod Shepal on October 6, 2009 at 4:43pm

Hello,
as nanoparticles are smaller, the greater its surface area to volume ratio and higher its chemical reactivity, and biological activity. as greater the chemical reactivity, results increased in production of ROS, including Free radicals- oxidative stress, inflammation, etc... primary mechanism of TOXICITY..
according to sum reports, there are certain nanoparticles tht may move into the sensitive lungs tissues after inhalation, and cause damage tht may leads to chronic breathing problems..
another e.g. is of Carbon Nanotubes, are frequently linked to the asbestos, tht can leads to Mesothelioma, cancer of lining of lungs becoz of asbestos, results observed during experimenting in abdominal cavity of mice using carbon NTs..

Permalink Reply by CH.L.R.Jaidev on October 8, 2009 at 7:28am

I am thankfull to everyone who had participated in this discussion by sharing some valuable information. I am also thankfull for the sugessions and expression of thier views on this discussion. With enriched information in mind and safisfaction in heart I would like to close this discussion. I am thankful to Nanopaprika for giving such a wonderful platform to interact with international nanotech research people.

with regards,
Ch.L.R.Jaidev.

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