cancer - The International NanoScience Community - Nanopaprika.eu2024-03-28T15:36:52Zhttps://www.nanopaprika.eu/groups/nanoposter-2021/forum/topics/feed/tag/cancerNP2021-014 Functionalized carbon nanotubes (F-CNTs): Promising delivery system for targeting cancer cellshttps://www.nanopaprika.eu/groups/nanoposter-2021/forum/topics/np2021-0142021-03-23T19:36:57.000Z2021-03-23T19:36:57.000ZTINChttps://www.nanopaprika.eu/members/TINC<div><p style="text-align:center;"><span style="font-size:14pt;"><strong>Functionalized carbon nanotubes (F-CNTs): Promising delivery system for targeting cancer cells</strong></span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><a href="https://www.nanopaprika.eu/members/DrMdAkhlaquerRahman" target="_blank">Md. Akhlaquer Rahman*</a>, Ranjit K Harwansh</span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><em>*College of Pharmacy, Taif University, Taif - 21974, Kingdom of Saudi Arabia.</em><br /> <em>Institute of Pharmaceutical Research, GLA University, Mathura - 281406, India.</em></span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><br /> * Presenting Author</span></p>
<p style="text-align:left;"><span style="font-size:14pt;">Cancer is one of the most leading cause of death worldwide, characterized by uncontrolled cell division and spread to other parts of the body causing metastasis. Treatment of cancer includes both chemotherapy and radiation therapy that utilizes the drugs and radiations, respectively. The available reports suggesting the use of nanoparticles in treatment of cancer due to declared properties like smaller particle size, large surface area as well as surface functionalization capacity that leads to increase in the internalization of therapeutics into cancer cells. Recently, carbon nanotubes (CNTs) have gained popularity for successful delivery of drugs, genetic and other biomaterials, owing to their excellent surface properties.<br /> The hollow interior surface offers an enormous cargo-carrying capacity for drug delivery; and their exteriors surface are readily functionalized to warrant tailoring of solubility and biological recognition. Despite their immense capabilities as drug delivery system, there use is constrained primarily because of its serious toxicity. However, surface functionalization capacity of CNTs permits the attachment of guest molecules which helps in increasing the biocompatibility of these nanocarriers. CNTs can be tailored with peptides and amino acids, organic molecules, carbohydrates, natural and synthetic polymers for cancer cell targeting and tumor accumulation. Hence, this novel nanocarrier offered a new opportunity for the formulation scientists to improve the potential use of therapeutics for treatment of cancer.</span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><a href="{{#staticFileLink}}8732396469,original{{/staticFileLink}}"><img class="align-center" src="{{#staticFileLink}}8732396876,RESIZE_710x{{/staticFileLink}}" width="710" alt="8732396876?profile=RESIZE_710x" /></a></span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><strong><a href="{{#staticFileLink}}8732396469,original{{/staticFileLink}}">NP21-014.pdf</a></strong></span></p>
<p style="text-align:left;"><span style="font-size:14pt;"><br /> <em>Keywords: Carbon nanotubes, Toxicity, Biocompatibility, Cellular uptake, Tumor accumulation, Surface functionalization</em></span></p></div>NP2021-006 Nano sized emulsion droplet systems of chemotherapeutic agents for management of prostate cancerhttps://www.nanopaprika.eu/groups/nanoposter-2021/forum/topics/np2021-0062021-03-02T16:35:51.000Z2021-03-02T16:35:51.000ZTINChttps://www.nanopaprika.eu/members/TINC<div><p style="text-align:center;"><span style="font-size:14pt;"><strong>Nano sized emulsion droplet systems of chemotherapeutic agents for management of prostate cancer</strong></span></p>
<p style="text-align:center;"><span style="font-size:14pt;">Sushmita Srivastava*, <a href="https://www.nanopaprika.eu/members/DrMdFaheemHaider" target="_blank">Md. Faheem Haider</a>**, Usama Ahmad</span><br /><span style="font-size:14pt;"><em>Faculty of Pharmacy, Integral University, Lucknow-226026, India</em></span></p>
<p style="text-align:center;"><span style="font-size:14pt;">*Presenting Author</span><br /><span style="font-size:14pt;">**Corresponding Author</span><br /><span style="font-size:14pt;">Address for correspondence: Dr. Md. Faheem Haider, Assistant Professor, Faculty of Pharmacy, Integral University, Lucknow-226026, India</span></p>
<p style="text-align:left;"><span style="font-size:14pt;">Prostate carcinoma is a widespread cancer that kills approximately 350,000 people per year in about 84 countries. Radiation, bisphosphonate therapy, and palliative chemotherapy are the most common treatments for metastatic disease. However, the biggest downside is that medication is disease-driven, and as a result, it becomes metastatic and needs care. The ability to revolutionize cancer management by nanoemulsion suggests a possible treatment for management of prostate cancer. The potential to revolutionise cancer care by using delivery vehicles like nanoemulsion indicates optimistic results in cancer research. Nanoemulsions are heterogeneous system of oil and water stabilized by surfactant molecules having globule size of 20-200nm. Small size makes it an effective dosage form to deliver chemotherapeutic drugs as they possess the ability to enter leaky tumour vasculature. Recent research on nano-emulsions has revealed their potential for repurposing herbal and synthetic drugs, as well as their combination, to target prostate cancer and create a readily accessible nanomedicine.</span></p></div>NP2021-005 Liposomes as an effective carrier system for pulmonary deliveryhttps://www.nanopaprika.eu/groups/nanoposter-2021/forum/topics/np2021-0052021-03-02T16:31:27.000Z2021-03-02T16:31:27.000ZTINChttps://www.nanopaprika.eu/members/TINC<div><p style="text-align:center;"><span style="font-size:14pt;"><strong>Liposomes as an effective carrier system for pulmonary delivery</strong></span></p>
<p style="text-align:center;"><span style="font-size:14pt;">Aisha Shahid*, Mohd. Muazzam Khan, <a href="https://www.nanopaprika.eu/members/DrUsamaAhmad" target="_blank">Usama Ahmad</a>**</span></p>
<p style="text-align:center;"><span style="font-size:14pt;">*Presenting Author<br /> ** Address for corresspondence: Dr. Usama Ahmad, Assistant Professor, Faculty of Pharmacy, Integral University, Lucknow-226026 (India)</span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><em>Faculty of Pharmacy, Integral University</em></span></p>
<p style="text-align:left;"><span style="font-size:14pt;">Cancer is a leading cause of mortality worldwide accounting about 9.6 million deaths in 2018 alone. Among all the cancers, lung cancer has the highest mortality for both men and women in the United States and China. According to the pathogenesis of lung carcinoma can be divided into small cell lung cancer and non-small cell lung cancer. Approximately 85% of the global population suffers from non-small cell lung cancer due to its high tumor metastasis level. Many therapies are available to manage lung carcinomas, like radiotherapy, immunotherapy, surgery, phototherapy and chemotherapy. Among all these therapies, surgery has been preferred for the early stage of lung cancer. However, they still have some limitations and poor outcomes with high costs. Among all therapies, chemotherapy has been one of the most used treatments for non-small cell lung cancer. The effect of conventional chemotherapy for lung cancer gives poor results without selectivity to the cancerous cells. However, nanoformulation like liposomes has shown promising results as an effective carrier system. Liposomes are composed of one or more lipid bilayers with spherical shape vesicles and an aqueous core. These can encapsulate both polar and non-polar components or drugs with less toxic effects and also the capability to modify the surface by using various targeting ligands like peptide, carbohydrates, polyethylene glycol, antibody, etc. For successful drug delivery and to increase the therapeutic efficacy, reduce drug metabolism and to enhance bioavailability various inhalation devices like dry powder inhalers (DPI), nebulizers, soft mist inhalers are used to deliver the liposomal loaded drugs directly to the lungs.</span></p>
<p style="text-align:left;"><span style="font-size:14pt;"><a href="{{#staticFileLink}}8662104061,original{{/staticFileLink}}"><img class="align-center" src="{{#staticFileLink}}8662104081,RESIZE_710x{{/staticFileLink}}" width="710" alt="8662104081?profile=RESIZE_710x" /></a></span></p>
<p style="text-align:center;"><span style="font-size:14pt;"><a href="{{#staticFileLink}}8662104061,original{{/staticFileLink}}">NP21-005.pdf</a></span></p></div>