an invisible (infrared) pulsed laser beam transmits a liquid (water) and is ablating a solid (gold) releasing stable nanoparticles (positively charged gold nanoparticle with negative solvatisation zeta potential) .

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Comment by SOORAJ S on February 13, 2012 at 4:23am

I am working on my course project titled " Laser induced assembly of gold nano particles into colloidal crystals". We are synthesising gold nano particles by nanopulsed laser(Nd-YAG second harmonic) ablation. How Laser parameters - wavelength,pulse width,fluence,repetition rate,scanning time affects the size and efficiency of the nanoparticles and which are the values for these factors to get maximum efficiency? we need to get nanoparticles have an average size less than 20nm.please help me.

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Comment by Subhash Chandra Singh on January 7, 2012 at 4:47pm

nice video of LAL

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Comment by Dr. Stephan Barcikowski on January 24, 2011 at 6:19pm

@ NANOSTROM, @ Phanjom:

No, this method is well established. It first reported in 1993. Now, we are a big community, with about 2 articles published per week. A summary on this can be found here: 

Barcikowski, S.; Devesa, F.; Moldenhauer, K.: Impact and structure of literature on nanoparticle generation by laser ablation in liquids. In: Journal of Nanoparticle Research 11 (2009), Nr. 8, S. 1883–1893


DOI: 10.1007/s11051-009-9765-0


In this video, a high-power picosecond laser was applied for this laser-based colloid synthesis for the first time. This allows to work in water or organic solvent at producttivities up to 1.3 g/h:

Bärsch, N.; Jakobi, J.; Weiler, S.;Barcikowski, S.: Pure colloidal metal and ceramic nanoparticles from high-power picosecond laser ablation in water and acetone. In: Nanotechnology 20 (2009), Nr. 44, 445603

Open access:



Moreover, under appropriate conditions, the nanoparticles can be fabricated also with nanosecond-pulsed laser in gram scale.

Sajti, C. L.; Sattari, R.; Chichkov, B. N.;Barcikowski, S.: Gram Scale Synthesis of Pure Ceramic Nanoparticles by Laser Ablation in Liquid. In: Journal of Physical Chemistry C 114 (2010), Nr. 6, S. 2421–2427


DOI: 10.1021/jp906960g



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Comment by NANOSTROM on January 22, 2011 at 1:17pm

Is this a newly discovered phenomenon? Can someone clarify?

Also, how about heat (entropy) generated by Laser beaming? Does it raise temp. of water?

Where can we get more information on this




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Comment by Probin Phanjom on January 22, 2011 at 11:20am

Hello Sir,

Its amazing...May i get to know more about it....

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Comment by Anand Kumar on May 13, 2010 at 8:46am
Seems quite interesting.
Can you let me know the economics of the process and investment required?

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Comment by Sohaib Zia Khan on October 6, 2009 at 8:48pm
Using a bio-compatible liquid is another way of getting nanoparticles with different surface condition. The application of this technique is seems to be unlimited.

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Comment by Dr. Stephan Barcikowski on June 8, 2009 at 9:16am
Dear Muhammad Ali,
in the field of molecular biology, this technique can be used to design nano-markers or nano-drugs via the so-calles 'in-situ bioconjugation', see
S. Petersen, S. Barcikowski In-situ Bioconjugation - Single Step Approach to Tailored Nanoparticle-Bioconjugates by Ultrashort Pulsed Laser Ablation. Adv. Funct. Mater. 2009, 19, 1167-1172

Regards, Stephan

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Comment by Muhammad Ali on June 8, 2009 at 7:16am
Laser generation of nanoparticles in liquids is a very interesting technique. Please give me some more information about its applications in the field of Biotechnology and Molecular Biology.

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Comment by Dr. Stephan Barcikowski on May 18, 2009 at 4:04pm
..sizes: e.g. Gold-DNA-Conjugate: 5 nm (TEM) +/- 12%. But bigger sizes (up to 35 nm) are possible, see below.
Another example are magnetig particles with a size around 50 nm.

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