TINC-Job Monitor: Investigating the nano-scale ordering of plasma-membrane anchored proteins

Our research focuses on the nano-scale organization of proteins in the plasma membrane of cells, and its role in signal transduction. The project is part of a collaborative effort with groups in the Netherlands and in the United Kingdom to manipulate and visualize plasma membrane proteins in a controlled fashion using rationally designed nano-objects. Our group focuses on investigating the nano-scale ordering of plasma-membrane anchored proteins, such as GPI-anchored proteins, and transmembrane receptors, such as the EGFR receptor, in living cells using advanced fluorescence microscopy methods. In collaboration with the partner groups we will perturb and probe these systems in living cells with rationally designed nano-objects and with atomic force microscopy.

The subject of the candidate’s work will be the investigation of the distribution of GPI-anchored proteins and the EGFR receptor at nano-meter scales, in living cells, using advanced fluorescence microscopy techniques, such as photoactivated localization microscopy (PALM) and fluorescence resonance energy transfer (FRET). He or she will closely collaborate with the project partners in the Netherlands and the United Kingdom, who will provide expertise on complementary approaches (i.e. chemical biology, generation of nano-probes, and atomic force microscopy).

The position is available immediately and is limited to a maximum of three years. The successful candidate should have a strong background in biology, biochemistry, or biophysics or related subjects. Candidates with a keen interest in systems biology, nanotechnology, and interdisciplinary research are encouraged to apply. The PhD-studentship is remunerated at 50% of the TVöD E13 salary scale.

The Max Planck Society wishes to employ more handicapped people. Applications of handicapped people are explicitly desired. Likewise, the Max-Planck-Society wishes to increase the proportion of women where they are underrepresented. Women are therefore explicitly invited to apply.

Fluorescence microscopy, Fluorescence resonance energy transfer, Fluorescence lifetime imaging, Anisotropy microscopy, Single molecule imaging, PALM/STORM microscopy

From: 1. Juni 2009 - 3 years

Homepage: http://www.mpi-dortmund.mpg.de/english/Start/Willkommen/index.html

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