Ref: 455/19195/BC
Closing date: 9th February 2015

Basal bodies organise the assembly and maintenance of cilia and flagella in eukaryotic cells. Most cells in the human body form a cilium or flagellum, which are required for either cell signaling and/or moving cells through fluid. Dysfunction of basal bodies, cilia and flagella are linked to a number of human diseases collectively called ciliopathies. Cilia and flagella are highly conserved cellular structures that are also required for cell motility and play an important role in the pathogenesis of a number of tropical parasites affecting Humans, including Trypanosoma brucei which causes African sleeping sickness. This project will investigate the early assembly steps of basal body duplication. The successful candidate will use a range of three dimensional bioimaging tools in our well-funded Bioimaging until including electron tomography and SBF-SEM and investigate the protein composition using a range of established molecular biology tools.

You will have:

• a degree in a biological topic
• a PhD in a biological topic
• Research experience in cell biology
• Research experience in biological imaging and electron microscopy
• An ability and willingness to carry out collaborative research with an international network.
• A strong background in electron microscopy and imaging software.

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