The UNCG Center for Translational Biomedical Research (CTBR), is a satellite to the Office of Research and Economic Development, and located at the North Carolina Research Campus (NCRC) in Kannapolis, NC (near Charlotte; ~70 miles SW of Greensboro). The center consists of two research groups, the Laboratory of Metabolomics and the Laboratory of Metabolic Liver Disease. The mission of the UNCG CTBR is to implement biomedical discoveries for understanding of disease pathogenesis and development of novel interventions for prevention and treatment.
The current research activities at the CTBR focus on metabolic diseases. Metabolism refers to all chemical reactions in the body cells to convert or use energy.
UNCG invites applications and nominations for a Post-Doctoral Fellowship position working under the direction of Dr. Qibin Zhang, at the Center for Translational Biomedical Research.
This position is expected to focus on discovery of intact protein markers proteolytically processed in vivo and correlated to disease progression in type 1 diabetes mellitus, using top-down proteomics approaches for an improved understanding of the pathogenic mechanism of this devastating pancreatic disorder, and a more accurate early diagnosis of type 1 diabetes. The ideal candidate may also have opportunity to collaborate with other research groups on profiling dysregulated intact proteins in other metabolic disorders, such as liver diseases, obesity, and other autoimmune diseases etc.
Specific duties include:
- Assisting the PI to establish a LC-MS based quantitative top-down proteomics capability at the Center;
- Conducting lab experiments including isolation of intact proteins from human plasma or human derived tissues;
- Operation of instruments for the separation and analysis of intact proteins and proteoforms using nano LC-MS/MS;
- Performing data base search, statistical data analysis and interpretation, and publication of results;
- Participating in the mechanistic investigation of type 1 diabetes, obesity, liver diseases and autoimmune diseases with collaborators;
- Assisting the PI to manage the research projects and supervise graduate and undergraduate students;
- Interacting with research programs and faculty from other institutions at NCRC, the David H. Murdock Research Institute, as well as other research facilities and faculties in the Chemistry, and Nutrition Department on the UNCG campus.
Comments