PhD Scholarship in Computational Studies of Protein Dynamics

A PhD position in Molecular Simulations is available from November 1, 2015 or shortly thereafter in the Lindorff-Larsen group at the Section for Biomolecular Sciences, Department of Biology, University of Copenhagen. The aim of the project is to integrate experimental and computational methods to study protein dynamics. The project funded by a Hallas-Moller Stipend from the Novo Foundation.

Research environment
The PhD student will work in the research group of Kresten Lindorff-Larsen. The group combines computational and experimental methods to study the structure, function and dynamics of proteins. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, drug resistance, and developing methods to integrate NMR spectroscopy and molecular simulations.

The Lindorff-Larsen group is located within the Section for Biomolecular Sciences at the Department of Biology that provides a strong, international environment for research broadly in the field of protein science. The Section currently employs about 25 PhD stu-dents and 10 Post Docs as well as a larger number of undergraduate students and guests. The research in the section is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The group is housed in the recently inaugurated Biocenter in central Copenhagen, Denmark (www.bio.ku.dk)

Project
The PhD student will use molecular dynamics simulations, integrated with experimental data and enhanced sampling methods, to study protein structure and dynamics. The goal is to develop and apply methods that are broadly applicable also to larger and more com-plex biomolecular systems.

Qualifications
Applicants should hold an MSc degree in e.g. chemistry, biophysics, biochemistry, nano-technology, physics or a closely related field. Candidates who do not yet have their MSc degree, but who are expecting to finish with 1–2 months, should specify the date when they expect to hand in their thesis.

The candidate must have:

(i) a strong background in protein science,
(ii) demonstrated research experience with performing all-atom molecular dynamics simulations,
(iii) experience with enhanced sampling methods and
(iv) experience with integrating experimental data into simulations.

In addition the above requirements, it is preferable that the candidate has experience in quantitative analyses of molecular dynamics simulations, as well as in applying such simulations to study protein dynamics. Candidates must have good interpersonal and communication skills. Fluency in spoken and written English is a requirement.

Application
Applicants are requested to submit their application below including:

- A cover letter (max. 1 page) describing your background, personal qualities, re-search interests and reasons for applying to this position
- Curriculum vitae (max. 2 pages)
- List of publications (if relevant) incl. papers that have been accepted for publication or are submitted
- Transcript of university examinations (in English)
- Contact details of 1-2 persons for references

Procedures
After the expiry of the deadline for applications, the authorized recruitment manager se-lects applicants for assessment on the advice of the Interview Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant himself/herself.

The final selection of successful candidates will be made by the Head of Department, based on the recommendations of the assessment committee. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of the Faculty of Science, University of Copenhagen. For more information: http://www.science.ku.dk/english/research/phd  

Terms of salary and employment
Terms of appointment and payment are in accordance with the agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). The starting salary for candidates with an MSc degree will be a minimum of DKK 306,667 (April 2015 level) plus pension contribution, with the possibility of salary negotiation.

The University of Copenhagen wishes to reflect the diversity of society and welcomes ap-plications from all qualified candidates regardless of personal background.

The deadline for applications is October 2, 2015.

Applications received after the deadline, or with insufficient documentation or otherwise not complying with the above requirements, may not be considered. It is expected that the successful candidate will be enrolled at the PhD School of the Faculty of Science starting November 1, 2015 or shortly thereafter.

Further information can be obtained via email to Associate Professor Kresten Lindorff-Larsen, e-mail: lindorff@bio.ku.dk, website: http://www.bio.ku.dk/sbinlab

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