Nanotech Journal Club: Differentially cross-linkable core–shell nanofibers for tunable delivery of anticancer drugs: synthesis, characterization and their anticancer efficacy

Differentially cross-linkable core–shell nanofibers for tunable delivery of anticancer drugs: synthesis, characterization and their anticancer efficacy

S. Uday Kumar, I. Matai, P. Dubey, B. Bhushan, A. Sachdev and P. Gopinath

Indian Institute of Technology Roorkee, Roorkee, Uttarakhand-247667, India.

This work introduces a new dimension for controlled drug delivery by nanofiber based scaffolds for anticancer therapy. The model anticancer drugs adopted in this work are curcumin and 5-fluorouracil (5-FU). Most of the drug loaded nanofibers synthesized thus far have failed to address the needs of personalized medication due to poor scalability of drug loading and delivery kinetics. This work opens up new avenues for circumventing such complications by altering the drug release profile by a simple one-step crosslinking reaction. With an aim to emphasize the role of polymer crosslinking in drug release kinetics, two variations of dual drug loaded core–shell nanofibers were synthesized with different extents of crosslinking and polymer composition. These two variations of drug loaded nanofibers exhibited contrasting 5-FU release profiles and thus manifested different therapeutic efficacy at different time points against A549 (Non-Small Cell Lung cancer) cells. The drug release profile of these fibers was further corroborated by different kinetic models to gain a perspective on the underlying mechanism driving the drug release from type I and type II nanofibers. The synergistic therapeutic potential of curcumin and 5-FU loaded core–shell nanofibers (type I and type II nanofibers) was also validated against A549 cells. As an outcome of this work, a clear correlation of cell viability with time lag in drug delivery in the case of type I and type II nanofibers could be drawn, which makes nanofiber based drug delivery even more flexible and therapeutically effective with minimal side effects.

Links to the paper (link to the journal webpage):

http://pubs.rsc.org/en/content/articlelanding/2014/ra/c4ra05001k#!d...

Views: 108

Comment

You need to be a member of The International NanoScience Community to add comments!

Join The International NanoScience Community


Full member
Comment by rajiv gandhi.s. on August 30, 2014 at 9:28am

Very important to anticancer drugs in medically,your synthesis are nano fibers highly fond with DNA and effectively inhibition of cancer cells 

Welcome - about us

Welcome! Nanopaprika was cooked up by Hungarian chemistry PhD student in 2007. The main idea was to create something more personal than the other nano networks already on the Internet. Community is open to everyone from post-doctorial researchers and professors to students everywhere.

There is only one important assumption: you have to be interested in nano!

Nanopaprika is always looking for new partners, if you have any idea, contact me at editor@nanopaprika.eu

Dr. András Paszternák, founder of Nanopaprika

Partner network:

Next partner events of TINC

We are Media Partner of:

Badge

Loading…

© 2019   Created by András Paszternák, PhD (founder).   Powered by

Badges  |  Report an Issue  |  Terms of Service