The department of NanoBiophotonics at the Max Planck Institute for Biophysical Chemistry (Director Prof. Dr. Stefan Hell) is seeking for a

PhD Student

for studying

Nanoscale lipid-protein membrane interactions and organization and their role in cellular signaling using super-resolution optical(STED)microscopy

Our department is developing, improving and applying super-resolution optical (far-field fluorescence) microscopy methods such as STED microscopy. The spatial resolution of conventional optical (far-field) microscopy is limited to about 200 nm and impedes the observation of cellular processes that occur on smaller spatial scales. Nanoscopes such as the STED microscope surpass this limit and allow the recording of cellular images with unprecedented resolution.

In the present project, STED microscopy is combined with fluorescence correlation spectroscopy (FCS) to study the role of nanoscopic lipid-protein interactions and their impact on cellular functionality. Prominent examples are for example EGF receptor functionality, viral uptake and budding of HIV, or B- and T-cell activation.

We are seeking an innovative and creative person with interest in approaching the above biological questions and in further developing and improving the current STED(-FCS) setup. We offer an open and stimulating research environment where she/he will have the opportunity to follow her/his own ideas and concepts. The know-how, infrastructure and equipment of the Department of NanoBiophotonics, which is among the worldwide leaders in high-resolution imaging, will be available. Payment will be according to the German TVoD standard. The position is available immediately.

The Max Planck Society is trying to increase the percentage of women on its scientific staff and strongly encourages applications from qualified women. The Society is also committed to employing more disabled persons and especially encourages them to apply.

Applications (preferably as single pdf file) and enquiries to

Dr. Christian Eggeling
Max Planck Institute for Biophysical Chemistry
Department NanoBiophotonics
Am Fassberg 11, 37077 Göttingen, Germany
Tel.: +49 – (0)551 - 201 2500
Email: ceggeli(a)gwdg.de
www.nanoscopy.de

 

C. Eggeling, C. Ringemann, R. Medda, G. Schwarzmann, K. Sandhoff, S. Polyakova. V. N. Belov, B. Hein, C. von Middendorff, A. Schönle, S. W. Hell Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature 457, 1159-1163 (2009).

V. Mueller, C. Ringemann, A. Honigmann, G. Schwarzmann, R. Medda, M. Leutenegger, S. Polyakova, V. N. Belov, S. W. Hell, C. Eggeling STED nanoscopy reveals molecular details of choleterol- and cytokeleton-modulated lipid interactions in living cells, Biophys. J., 101, 1651-1657 (2011).

Homepage: http://www.nanoscopy.de

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