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The LSm protein Hfq hexamer torus showing the peptide backbone, with each protein in a different color, representing each beta strand as a ribbon, each alpha helix as a cylinder, and the RNA oligonucleotide as a 300° arc.


LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules.

The Sm proteins were first discovered as antigens targeted by so called Anti-Sm antibodies in a patient with a form of systemic lupus erythematosus (SLE), a debilitating autoimmune disease. They were named Sm proteins in honor of this patient, Stephanie Smith. Other proteins with very similar structures were subsequently discovered and named LSm proteins. New members of the LSm protein family continue to be identified and reported.


Proteins with similar structures are grouped into a hierarchy of protein families, superfamilies and folds. The LSm protein structure is an example of a small beta sheet folded into a short barrel. Individual LSm proteins assemble into a six or seven member doughnut ring (more properly termed a torus), which usually binds to a small RNA molecule to form a ribonucleoprotein complex. The LSm torus assists the RNA molecule to assume and maintain its proper three dimensional structure. Depending on which LSm proteins and RNA molecule are involved, this ribonucleoprotein complex facilitates a wide variety of RNA processing including degradation, editing, splicing, and regulation.


Image Source: National Center for Biotechnology Information of the National Library of Medicine at the National Institutes of Health (USA).
Text Source: Wikipedia

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Tags: LSm_protein, RNA, SLE, alpha_helix, beta, complex, erythematosus, lupus, peptide_backbone, protein-folding, More…ribonucleoprotein, self-assembly, sheet, systemic

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Publications by A. Paszternák:

Directed Deposition of Nickel Nanoparticles Using Self-Assembled Organic Template,

Polymeric Honeycombs Decorated by Nickel Nanoparticles, Science of Advanced Materials (Accepted, 05/2014)

Organometallic deposition of ultrasmooth nanoscale Ni film,

Zigzag-shaped nickel nanowires via organometallic template-free route

Surface analytical characterization of passive iron surface modified by alkyl-phosphonic acid layers

Atomic Force Microscopy Studies of Alkyl-Phosphonate SAMs on Mica

Amorphous iron formation due to low energy heavy ion implantation in evaporated 57Fe thin films

Surface modification of passive iron by alkylphosphonic acid layers

Formation and structure of alkylphosphonic acid layers on passive iron

Structure of the nonionic surfactant triethoxy monooctylether C8E3 adsorbed at the free water surface, as seen from surface tension measurements and Monte Carlo simulations

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